Journal article
Lymphocyte subsets in relapsing-remitting Multiple Sclerosis: A longitudinal study of B lymphocytes and T lymphocytes
Neurological research (New York), v 16(5), pp 385-388
01 Oct 1994
PMID: 7870278
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes in lymphocyte subset populations may provide dues to the dysimmune mechanisms involved in relapsing remitting multiple sclerosis (RRMS). The lymphocyte subgroup CD4+CD45RA+, thought to be responsible for the induction of suppression is decreased in some patients with MS compared to controls. A possible role for another lymphocyte subset, CD19+CD5+ lymphocytes; has been proposed in autoimmune diseases and multiple sclerosis (MS). To expand this we studied CD4+CD45RA + (T) lymphocytes and CD19+CD5+ (B) lymphocytes in nine patients with relapsing-remitting MS (RRMS) and nine controls. The patients were examined monthly for an average of ten months and nine relapses were observed in seven patients. One patient underwent monthly gadolinium enhanced magnetic resonance imaging (MRI). Normal percentages CD4+CD45RA+ lymphocytes were found in patients with RRMS. No significant abnormalities in the CD19+CD5+ lymphocyte subpopulation were noted, although a tendency for higher percentages of this subset (approaching statistical significance, P = 0.056) was detected. [Neurol Res 1994; 16: 385-388]
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Details
- Title
- Lymphocyte subsets in relapsing-remitting Multiple Sclerosis: A longitudinal study of B lymphocytes and T lymphocytes
- Creators
- Thomas F. Scott - Allegheny General HospitalJohn McKolanis - Clinical Oncology LabWilliam Rothfus - Department of RadiologyEric Cottington - Allegheny General Hospital
- Publication Details
- Neurological research (New York), v 16(5), pp 385-388
- Publisher
- Taylor & Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:A1994PP00800009
- Scopus ID
- 2-s2.0-0028104238
- Other Identifier
- 991019183929004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences