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Journal article
Lysophosphatidic acid differentially regulates axonal mRNA translation through 5 ' UTR elements
Molecular and cellular neuroscience, v 50(2), pp 136-146
01 Jun 2012
PMID: 22522146
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sensory neurons transport a complex population of mRNAs into their axons, including many encoding ER chaperone proteins. Transport of the mRNA encoding the ER chaperone protein calreticulin is regulated through 3'UTR elements. In other cellular systems, translation of chaperone protein mRNAs can be regulated by ER stress. Here, we have asked if the translation of axonal calreticulin mRNA is regulated in a different manner than its transport into axons. Treatment with lysophosphatidic acid, which is known to trigger axon retraction and stimulate ER Ca2+ release, caused a translation-dependent increase in axonal calreticulin protein levels. RNA sequences in the 5'UTR of calreticulin confer this translational control through a mechanism that requires an inactivating phosphorylation of elF2 alpha. In contrast to calreticulin, these signaling events do not activate axonal translation through beta-actin's 5'UTR. Together, these data indicate that stimulation of ER stress can regulate specificity of localized mRNA translation through 5'UTR elements.
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- Title
- Lysophosphatidic acid differentially regulates axonal mRNA translation through 5 ' UTR elements
- Creators
- Deepika Vuppalanchi - University of DelawareTanuja T. Merianda - Alfred I DuPont Hosp Children, Nemours Biomed Res, Wilmington, DE USAChristopher Donnelly - University of DelawareAlmudena Pacheco - Drexel UniversityGervan Williams - Alfred I. duPont Hospital for ChildrenSoonmoon Yoo - Alfred I DuPont Hosp Children, Nemours Biomed Res, Wilmington, DE USARajiv R. Ratan - Burke Medical Research InstituteDianna E. Willis - Burke Medical Research InstituteJeffery L. Twiss - Drexel University
- Publication Details
- Molecular and cellular neuroscience, v 50(2), pp 136-146
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- Craig H. Neilsen Foundation R01NS041596 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01-NS041596; K99-NR010797 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Miriam and Sheldon G. Adelson Medical Research Foundation K99NR010797 / NATIONAL INSTITUTE OF NURSING RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000306304300002
- Scopus ID
- 2-s2.0-84861450458
- Other Identifier
- 991021892106404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences