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MEF-2 isoforms' (A-D) roles in development and tumorigenesis
Journal article - Review   Open access

MEF-2 isoforms' (A-D) roles in development and tumorigenesis

Kiran Madugula, Ria Mulherkar, Zafar K. Khan, DeGaulle I. Chigbu, Dip Patel, Edward W. Harhaj and Pooja Jain
Oncotarget, v 10(28), pp 2755-2787
12 Apr 2019
DOI: https://doi.org/10.18632/oncotarget.26763
PMID: 31105874
url
https://doi.org/10.18632/oncotarget.26763View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

ATLL HDACi HDACs HTLV-1 MEF-2 Review
Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.

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