Journal article
MEF Promotes Stemness in the Pathogenesis of Gliomas
Cell stem cell, v 11(6), pp 836-844
07 Dec 2012
PMID: 23217424
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.
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Details
- Title
- MEF Promotes Stemness in the Pathogenesis of Gliomas
- Creators
- Elena Bazzoli - Azienda Ospedaliera Universitaria Integrata VeronaTeodoro Pulvirenti - Memorial Sloan Kettering Cancer CenterMoritz C. Oberstadt - Memorial Sloan Kettering Cancer CenterFabiana Perna - Memorial Sloan Kettering Cancer CenterBoyoung Wee - Memorial Sloan Kettering Cancer CenterNikolaus Schultz - Memorial Sloan Kettering Cancer CenterJason T. Huse - Memorial Sloan Kettering Cancer CenterElena I. Fomchenko - Memorial Sloan Kettering Cancer CenterFrancesca Voza - Memorial Sloan Kettering Cancer CenterViviane Tabar - Memorial Sloan Kettering Cancer CenterCameron W. Brennan - Memorial Sloan Kettering Cancer CenterLisa M. DeAngelis - Memorial Sloan Kettering Cancer CenterStephen D. Nimer - Memorial Sloan Kettering Cancer CenterEric C. Holland - Memorial Sloan Kettering Cancer CenterMassimo Squatrito - Memorial Sloan Kettering Cancer Center
- Publication Details
- Cell stem cell, v 11(6), pp 836-844
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Brain Tumor Center of Memorial Sloan-Kettering Cancer Center Gerhard Domagk Scholarship Program, Greifswald, Germany Rottendorf Foundation, Ennigerloh, Germany U01CA141502 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) RO1-DK52208; U54CAI43798; UO1CA141502; RO1CA100688 / National Brain Tumor Foundation R01DK052208 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000312420300014
- Scopus ID
- 2-s2.0-84870871140
- Other Identifier
- 991022004959404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell & Tissue Engineering
- Cell Biology