Journal article
MIDLINE BRAIN INJURY IN THE IMMATURE RAT INDUCES SUSTAINED COGNITIVE DEFICITS, BIHEMISPHERIC AXONAL INJURY AND NEURODEGENERATION
Experimental neurology, v 213(1)
Sep 2008
PMID: 18599043
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Infants and children less than 4 years old suffer chronic cognitive deficits following mild, moderate or severe diffuse traumatic brain injury (TBI). It has been suggested that the underlying neuropathologic basis for behavioral deficits following severe TBI is acute brain swelling, subarachnoid hemorrhage and axonal injury. To better understand mechanisms of cognitive dysfunction in mild-moderate TBI, a closed head injury model of midline TBI in the immature rat was developed. Following an impact over the midline suture of the intact skull, 17-day-old rats exhibited short apnea times (3–15 seconds), did not require ventilatory support and suffered no mortality, suggestive of mild TBI. Compared to un-injured rats, brain-injured rats exhibited significant learning deficits over the first week post-injury (P<0.0005), and, significant learning (P<0.005) and memory deficits (P<0.05) in the third post-injury week. Between 6 and 72h, blood-brain barrier breakdown, extensive traumatic axonal injury in the subcortical white matter and thalamus, and focal areas of neurodegeneration in the cortex and hippocampus were observed in
both
hemispheres of the injured brain. At 8 to 18 days post-injury, reactive astrocytosis in the cortex, axonal degeneration in the subcortical white matter tracts, and degeneration of neuronal cell bodies and processes in the thalamus of
both
hemispheres were observed; however, cortical volumes were not different between un-injured and injured rat brains. These data suggest that diffuse TBI in the immature rat can lead to ongoing degeneration of both cell soma and axonal compartments of neurons, which may contribute, in part, to the observed sustained cognitive deficits.
Metrics
Details
- Title
- MIDLINE BRAIN INJURY IN THE IMMATURE RAT INDUCES SUSTAINED COGNITIVE DEFICITS, BIHEMISPHERIC AXONAL INJURY AND NEURODEGENERATION
- Creators
- Jimmy W Huh - Department of Anesthesiology and Critical Care, Children’s Hospital of Philadelphia, Philadelphia, PA 19104Ashley G Widing - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129Ramesh Raghupathi - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129
- Publication Details
- Experimental neurology, v 213(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000258943500010
- Scopus ID
- 2-s2.0-49349097133
- Other Identifier
- 991014878233604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences