Journal article
MMR vaccination and autism--a population-based follow-up study
Ugeskrift for læger, v 164(49), pp 5741-5744
02 Dec 2002
PMID: 12523209
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
INTRODUCTIONIt has been suggested that the measles-mumps-rubella (MMR) vaccination causes autism.MATERIAL AND METHODSWe conducted a retrospective cohort study of all children born in Denmark from January 1991 through December 1998. The cohort was established based on data from the Danish Civil Registration System. A unique person identifiable number given to all subjects enabled linkage with other national registries. MMR vaccination status was obtained from the Danish National Board of Health. Information on the children's autism status was obtained from the Danish Psychiatric Central Register which contains information on all diagnoses received from psychiatric hospitals, psychiatric wards, and outpatient clinics in Denmark. We obtained information on potential confounders from the Danish Medical Birth Registry, the National Hospital Registry, and Statistics Denmark.RESULTSIn the cohort of 537,303 children (2,129,864 person-years), 440,655 children had been MMR vaccinated. We identified 316 children with a diagnosis of autistic disorder and 442 with a diagnosis of other spectrum disorders. After adjusting for potential confounders, the risk for autistic disorder and other spectrum disorders was not increased in vaccinated compared with unvaccinated children (relative risk 0.92; 95 percent confidence interval, 0.68 to 1.24 and relative risk 0.83; 95 percent confidence interval, 0.65 to 1.07). There was no association between age at vaccination, time since vaccination or calendar period at time of vaccination and development of autistic disorder.DISCUSSIONThis study provides strong evidence against the hypothesis that MMR vaccination causes autism.
Metrics
10 Record Views
Details
- Title
- MMR vaccination and autism--a population-based follow-up study
- Creators
- Kreesten Meldgaard MadsenAnders HviidMogens VestergaardDiana SchendelJan WohlfahrtPoul ThorsenJørn OlsenMads Melbye
- Publication Details
- Ugeskrift for læger, v 164(49), pp 5741-5744
- Resource Type
- Journal article
- Language
- Danish
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000179724800001
- Scopus ID
- 2-s2.0-0037011202
- Other Identifier
- 991021463577704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, General & Internal