Journal article
MODULATION BY BIOLOGIC RESPONSE MODIFIERS OF HEPATITIS C VIRUS ANTIGEN-INDEPENDENT CYTOKINE SECRETION IN BLOOD MONONUCLEAR CELLS
Cytokine (Philadelphia, Pa.), v 11(4), pp 267-273
01 Apr 1999
PMID: 10328865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The systemic hepatitis C virus (HCV) antigen-non-specific cytokine responses were investigated in cultures of peripheral blood mononuclear cells. Cytokines of the T helper (Th) 1 [interferon (IFN)γ and interleukin (IL)-2] and Th2 (IL-4 and IL-10) phenotype, and the pro-inflammatory cytokines tumour necrosis factor αIL-1β and IL-6, were secreted by the cells activated by the HCV antigen-independent pathway. Furthermore, these cytokine responses were shifted towards a Th1 predominance by treatment with IFN-β and with IL-2, whereas cytokine responses were selectively amplified towards a combined Th1-Th2 profile by granulocyte-macrophage- but not by macrophage colony-stimulating factor. Moreover, pro-inflammatory cytokine production was significantly enhanced by IFN-β and augmented dose-dependently with GM-CSF and IL-2. Therefore, these immune mediators can promote unique—as well as overlapping—systemic cytokine responses that may be relevant for immunotherapeutic interventions to control HCV infection.
Metrics
Details
- Title
- MODULATION BY BIOLOGIC RESPONSE MODIFIERS OF HEPATITIS C VIRUS ANTIGEN-INDEPENDENT CYTOKINE SECRETION IN BLOOD MONONUCLEAR CELLS
- Creators
- Julio Martı́nJuan Antonio Quiroga - Hospital Universitario Fundación Jiménez DíazMargarita Pardo - Fundación para el Estudio de las Hepatitis ViralesSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Cytokine (Philadelphia, Pa.), v 11(4), pp 267-273
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000080101000003
- Scopus ID
- 2-s2.0-0033119063
- Other Identifier
- 991022047819804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology