Journal article
MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis
American journal of neuroradiology : AJNR, v 20(10), pp 1951-1955
01 Nov 1999
PMID: 10588124
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Abstract
BACKGROUND AND PURPOSE:
Multiple sclerosis (MS) is a demyelinating disease most often associated with progressive physical impairment; however, its effects are noted to extend beyond physical disability. Our purpose was to determine the relationship between T2 lesion volume and neurocognitive and physical disability in relapsing-remitting multiple sclerosis.
METHODS:
We studied a cohort of 19 patients with relapsing-remitting MS. Of this group, there were 15 women and four men from varying socioeconomic backgrounds. This volunteer sample was selected from a larger group of 53 patients with MS in our longitudinal MS study because they had been untreated with any beta-interferon medications, had been followed for at least 12 months, and had a clinical status of relapsing-remitting MS.
RESULTS:
Of 12 neurocognitive parameters tested, two correlated significantly with lesion loads. The correlation of the Symbol-Digit Modalities test, which analyzes information-processing speed, was significant (
P
= .0204). The correlation of the fifth trial of the Rey Auditory Verbal Learning test, which tests verbal long-term memory, was also significant (
P
= .0348). None of the other 10 neurocognitive examinations, however, showed a significant correlation with total lesion volume (Paced Auditory Serial Addition test-1.6,
P
= .7381; Paced Auditory Serial Addition test-2.0,
P
= .4180; Controlled Oral Word Association test,
P
= .8906; Category Fluency test,
P
= .4423; Bells test,
P
= .9097; Rey Auditory Verbal Learning test-delay,
P
= .9843, Rey Auditory Verbal Learning test-recognition,
P
= .7467; Word Span test,
P
= .4939; Road Map test,
P
= 0.4939). The lesion load also did not correlate with the physical disability scales as rated according to the Expanded Disability Status Scale (
P
= .68) or Ambulation Index (
P
= .95).
CONCLUSION:
Our results indicate that T2 lesion volume does not seem to be a robust surrogate marker of neuropsychological impairment in patients with MS. We think that global measurements of parameters that are more specific to the disease process may offer more precise correlation with cognitive dysfunction and other disability parameters.
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Details
- Title
- MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis
- Creators
- Jennifer C. Fulton - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PARobert I. Grossman - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PAJayaram Udupa - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PALois J. Mannon - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PAMurray Grossman - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PALuogang Wei - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PAMarcia Polansky - Hospital of the University of PennsylvaniaDennis L. Kolson - From the Departments of Radiology (J.C.F., R.I.G., J.U., L.J.M., L.W.) and Neurology (D.L.K.), Hospital of the University of Pennsylvania, and the Division of Biometrics (M.P.), Hahnemann University, Philadelphia, PA
- Publication Details
- American journal of neuroradiology : AJNR, v 20(10), pp 1951-1955
- Publisher
- American Society of Neuroradiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000083887500031
- Scopus ID
- 2-s2.0-0032692509
- Other Identifier
- 991019169662904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neuroimaging
- Radiology, Nuclear Medicine & Medical Imaging