Journal article
MRSA otorrhea: A case series and review of the literature
Ear, nose, & throat journal, v 90(2)
01 Feb 2011
PMID: 21328227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) has become an increasingly common cause of difficult-to-treat head and neck infections. We report a retrospective analysis of 3 cases of MRSA otorrhea treated in our clinic between 2007 and 2009. Culture analysis of otorrhea isolates revealed MRSA infections with identical drug sensitivities. Treatment success was achieved using combinations of linezolid with gentamicin ear drops for 3 to 4 weeks or trimethoprim/sulfamethoxazole (TMP/SMX) with gentamicin drops for 6 weeks. This study illustrates the importance of determining individual drug sensitivities for optimal treatment and maintaining current knowledge of the local MRSA strains. Empiric combination therapy of TMP/SMX with gentamicin is an effective first-line treatment for MRSA otorrhea. Regional differences in clindamycin sensitivities warrant clinical discretion. Fluoroquinolones should be avoided because of high rates of resistance unless culture sensitivity determines that they are appropriate. First-line agents for severe infections include combination therapy with vancomycin or linezolid.
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Details
- Title
- MRSA otorrhea: A case series and review of the literature
- Creators
- Katherine M. Baugher - Philadelphia College of Osteopathic MedicineTroy Sommers Hemme - Philadelphia College of Osteopathic MedicineMary Hawkshaw - Drexel UniversityRobert T. Sataloff - Drexel University
- Publication Details
- Ear, nose, & throat journal, v 90(2)
- Publisher
- Sage
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000290287800005
- Scopus ID
- 2-s2.0-84867380661
- Other Identifier
- 991019168038304721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology