Journal article
MTHFR Gene Polymorphism Is Associated With DNA Hypomethylation and Genetic Damage Among Benzene-Exposed Workers in Southeast China
Journal of occupational and environmental medicine, v 60(4), pp E188-E192
01 Apr 2018
PMID: 29370017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective and Methods:To analyze the association between global DNA methylation and single-nucleotide polymorphisms (SNPs) in methylenetetrahydrofolate reductase (MTHFR). MTHFR polymorphisms rs1801133 and rs1801131 were detected using the restriction fragment length polymorphism method, and cytokinesis-block micronucleus (MN) frequency and global DNA methylation was measured in workers from 410 shoe factories.Results:A multilinear regression analysis demonstrated that DNA methylation of the TT variant allele of rs1801133 was lower than that of the CC wild type allele (Exp() [95% CI], 0.76 [0.56, 1.02], P=0.071), with a P-value approaching significance. A significantly increased MN frequency was observed for carriers of the TT genotype (frequency ratio=1.27, 95% CI: 1.07-1.51, P<0.01).Conclusion:The results imply that the TT genotype in rs1801133 is associated with global DNA hypomethylation, which may influence the induction of MN following exposure to benzene.
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Details
- Title
- MTHFR Gene Polymorphism Is Associated With DNA Hypomethylation and Genetic Damage Among Benzene-Exposed Workers in Southeast China
- Creators
- Jing-chao Ren - Xinxiang Med Univ, Sch Publ Hlth, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Peoples R ChinaYu-xia Wu - Xinxiang Med Univ, Sch Publ Hlth, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Peoples R ChinaZhenzhen WuGuang-hui Zhang - Xinxiang Med Univ, Sch Publ Hlth, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Peoples R ChinaHongjian Wang - Puyang Peoples Hosp, Puyang, Peoples R ChinaHongzhou Liu - Puyang Peoples Hosp, Puyang, Peoples R ChinaJun-peng Cui - Xinxiang Med Univ, Sch Publ Hlth, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Peoples R ChinaQing Chen - Third Mil Med Univ, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R ChinaJinyi Liu - Third Mil Med Univ, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R ChinaArthur Frank - Drexel UniversityJia Cao - Xinxiang Med Univ, Sch Publ Hlth, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Peoples R ChinaZhao-lin Xia - Fudan Univ, Sch Publ Hlth, Dept Occupat Hlth & Toxicol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China
- Publication Details
- Journal of occupational and environmental medicine, v 60(4), pp E188-E192
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- NSFC 81474929; 81602836 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) XTCX-2015-PY3 / Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000429441900006
- Scopus ID
- 2-s2.0-85045132818
- Other Identifier
- 991019169000404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health