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Journal article
MXene Sorbents for Removal of Urea from Dialysate: A Step toward the Wearable Artificial Kidney
ACS nano, v 12(10), pp 10518-10528
23 Oct 2018
PMID: 30257087
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The wearable artificial kidney can deliver continuous ambulatory dialysis for more than 3 million patients with end-stage renal disease. However, the efficient removal of urea is a key challenge in miniaturizing the device and making it light and small enough for practical use. Here, we show that two-dimensional titanium carbide (MXene) with the composition of Ti3C2T x , where T x represents surface termination groups such as −OH, −O–, and −F, can adsorb urea, reaching 99% removal efficiency from aqueous solution and 94% from dialysate at the initial urea concentration of 30 mg/dL, with the maximum urea adsorption capacity of 10.4 mg/g at room temperature. When tested at 37 °C, we achieved a 2-fold increase in urea removal efficiency from dialysate, with the maximum urea adsorption capacity of 21.7 mg/g. Ti3C2T x showed good hemocompatibility; it did not induce cell apoptosis or reduce the metabolizing cell fraction, indicating no impact on cell viability at concentrations of up to 200 μg/mL. The biocompatibility of Ti3C2T x and its selectivity for urea adsorption from dialysate open a new opportunity in designing a miniaturized dialysate regeneration system for a wearable artificial kidney.
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Details
- Title
- MXene Sorbents for Removal of Urea from Dialysate: A Step toward the Wearable Artificial Kidney
- Creators
- Fayan Meng - Guangxi Medical UniversityMykola Seredych - A.J. Drexel Nanomaterials Institute, and Materials Science and Engineering DepartmentChi Chen - School of Optical and Electronic InformationVictor Gura - Cedars Sinai Medical Center, The David Geffen School of Medicine, UCLASergey Mikhalovsky - ANAMAD Ltd, Sussex Innovation CentreSusan Sandeman - Biomaterials and Medical Devices Research Group, School of Pharmacy and Biomolecular SciencesGanesh Ingavle - Symbiosis International UniversityTochukwu Ozulumba - Biomaterials and Medical Devices Research Group, School of Pharmacy and Biomolecular SciencesLing Miao - School of Optical and Electronic InformationBabak Anasori - A.J. Drexel Nanomaterials Institute, and Materials Science and Engineering DepartmentYury Gogotsi - A.J. Drexel Nanomaterials Institute, and Materials Science and Engineering Department
- Publication Details
- ACS nano, v 12(10), pp 10518-10528
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000448751800090
- Scopus ID
- 2-s2.0-85054359216
- Other Identifier
- 991014970024304721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology