Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation
Science translational medicine, v 13(612), pp eabf8629-eabf8629
22 Sep 2021
PMID: 34550728
Abstract
Soft bioelectronic interfaces for mapping and modulating excitable networks at high resolution and at large scale can enable paradigm-shifting diagnostics, monitoring, and treatment strategies. Yet, current technologies largely rely on materials and fabrication schemes that are expensive, do not scale, and critically limit the maximum attainable resolution and coverage. Solution processing is a cost-effective manufacturing alternative, but biocompatible conductive inks matching the performance of conventional metals are lacking. Here, we introduce MXtrodes, a class of soft, high-resolution, large-scale bioelectronic interfaces enabled by Ti
C
MXene (a two-dimensional transition metal carbide nanomaterial) and scalable solution processing. We show that the electrochemical properties of MXtrodes exceed those of conventional materials and do not require conductive gels when used in epidermal electronics. Furthermore, we validate MXtrodes in applications ranging from mapping large-scale neuromuscular networks in humans to cortical neural recording and microstimulation in swine and rodent models. Last, we demonstrate that MXtrodes are compatible with standard clinical neuroimaging modalities.
Metrics
Details
- Title
- MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation
- Creators
- Nicolette Driscoll - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Brian Erickson - Drexel UniversityBrendan B Murphy - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Andrew G Richardson - University of PennsylvaniaGregory Robbins - University of PennsylvaniaNicholas V Apollo - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Georgios Mentzelopoulos - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Tyler Mathis - Drexel UniversityKanit Hantanasirisakul - Drexel UniversityPuneet Bagga - St. Jude Children's Research HospitalSarah E Gullbrand - McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USAMatthew Sergison - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Ravinder Reddy - University of PennsylvaniaJohn A Wolf - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.H Isaac Chen - Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Timothy H Lucas - University of PennsylvaniaTimothy R Dillingham - University of PennsylvaniaKathryn A Davis - University of PennsylvaniaYury Gogotsi - Drexel UniversityJohn D Medaglia - Drexel UniversityFlavia Vitale - University of PennsylvaniaDrexel Univ., Philadelphia, PA (United States)
- Publication Details
- Science translational medicine, v 13(612), pp eabf8629-eabf8629
- Publisher
- American Association for the Advancement of Science (AAAS)
- Grant note
- K12 HD073945 / NICHD NIH HHS R01 NS121219 / NINDS NIH HHS T32 NS091006 / NINDS NIH HHS IK2 RX003118 / RRD VA DP5 OD021352 / NIH HHS P41 EB015893 / NIBIB NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); Materials Science and Engineering
- Web of Science ID
- WOS:000699896400003
- Scopus ID
- 2-s2.0-85116737457
- Other Identifier
- 991019169460104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Medicine, Research & Experimental