Journal article
Macitentan (Opsumit) for the treatment of pulmonary arterial hypertension
Expert review of clinical pharmacology, v 7(4), pp 415-421
01 Jul 2014
PMID: 24851934
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The endothelin pathway is a key pathway for the pathogenesis of pulmonary arterial hypertension (PAH). Antagonism of this pathway is recommended as initial therapy in low-risk patient with PAH to inhibit fibrosis, cell proliferation, and inflammation caused by endothelin. Prior to October 2013, ambrisentan, a selective ETA receptor antagonist and bosentan, a dual ETA/ETB antagonist, were the only currently available agents for PAH targeting the endothelin pathway. Based on the results of the SERAPHIN trial, macitentan (brand name Opsumit®), a new ETA/ETB antagonist, has been US FDA approved to delay disease progression and reduce hospitalizations for PAH. SERAPHIN is the first ERA trial to use an event-driven strategy with a composite primary end point of morbidity or mortality. Previous trials have focused on short-term outcomes, such as improved 6-min walk distance and WHO functional class.
Metrics
Details
- Title
- Macitentan (Opsumit) for the treatment of pulmonary arterial hypertension
- Creators
- Megan Clarke - Allegheny General HospitalClaire Walter - Allegheny General HospitalRicha Agarwal - Allegheny General HospitalManreet Kanwar - Allegheny General HospitalRaymond L Benza - Allegheny General Hospital
- Publication Details
- Expert review of clinical pharmacology, v 7(4), pp 415-421
- Publisher
- Informa UK, Ltd
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:000350021500005
- Scopus ID
- 2-s2.0-84903214463
- Other Identifier
- 991021932194304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy