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Journal article
Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus
Journal of virology, v 82(3), pp 1615-1621
Feb 2008
PMID: 18045942
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.
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Details
- Title
- Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus
- Creators
- Peter J Gaskill - Scripps Research InstituteMichelle Zandonatti - Molecular and Integrative Neurosciences DepartmentTim Gilmartin - Scripps Research InstituteSteven R Head - Scripps Research InstituteHoward S Fox - Molecular and Integrative Neurosciences Department
- Publication Details
- Journal of virology, v 82(3), pp 1615-1621
- Publisher
- American Society for Microbiology (ASM)
- Grant note
- R01 NS045534 / NINDS NIH HHS T32 AI07606 / NIAID NIH HHS R01 MH073490 / NIMH NIH HHS GM62116 / NIGMS NIH HHS T32 AI007606 / NIAID NIH HHS MH062261 / NIMH NIH HHS NS045534 / NINDS NIH HHS P30 MH062261 / NIMH NIH HHS MH073490 / NIMH NIH HHS U54 GM062116 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000252514000057
- Scopus ID
- 2-s2.0-38349157340
- Other Identifier
- 991020100071504721
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- Web of Science research areas
- Virology