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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing
Annals of biomedical engineering, v 43(3), pp 616-627
2015
PMID: 25331098
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tissue engineering is increasingly based on recapitulating human physiology, through integration of biological principles into engineering designs. In spite of all progress in engineering functional human tissues, we are just beginning to develop effective methods for establishing blood perfusion and controlling the inflammatory factors following implantation into the host. Functional vasculature largely determines tissue survival and function
in vivo
. The inflammatory response is a major regulator of vascularization and overall functionality of engineered tissues, through the activity of different types of macrophages and the cytokines they secrete. We discuss here the cell–scaffold–bioreactor systems for harnessing the inflammatory response for enhanced tissue vascularization and healing. To this end, inert scaffolds that have been considered for many decades a “gold standard” in regenerative medicine are beginning to be replaced by a new generation of “smart” tissue engineering systems designed to actively mediate tissue survival and function.
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Details
- Title
- Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing
- Creators
- Kara L. Spiller - Drexel UniversityDonald O. Freytes - New York Stem Cell FoundationGordana Vunjak-Novakovic - Columbia University
- Publication Details
- Annals of biomedical engineering, v 43(3), pp 616-627
- Publisher
- Springer US
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000351742500012
- Scopus ID
- 2-s2.0-84938216634
- Other Identifier
- 991019168216104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical