Journal article
Magnetic Nanoparticle-Mediated Targeting of Cell Therapy Reduces In-Stent Stenosis in Injured Arteries
ACS nano, v 10(10), pp 9559-9569
01 Oct 2016
PMID: 27622988
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although drug-eluting stents have dramatically reduced the recurrence of restenosis after vascular interventions, the nonselective antiproliferative drugs released from these devices significantly delay reendothelialization and vascular healing, increasing the risk of short- and long-term stent failure. Efficient repopulation of endothelial cells in the vessel wall following injury may limit complications, such as thrombosis, neoatherosclerosis, and restenosis, through reconstitution of a luminal barrier and cellular secretion of paracrine factors. We assessed the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit in-stent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. ECs loaded with biodegradable superparamagnetic nanoparticles (MNPs) were administered at the distal end of the stented artery and localized to the stent using a brief exposure to a uniform magnetic field. After two months, magnetic localization of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis. The study thus demonstrates that magnetically assisted delivery of ECs is a promising strategy for prevention of vessel lumen narrowing after stent angioplasty procedure.
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Details
- Title
- Magnetic Nanoparticle-Mediated Targeting of Cell Therapy Reduces In-Stent Stenosis in Injured Arteries
- Creators
- Boris Polyak - Drexel UniversityMikhail Medved - Drexel UniversityNina Lazareva - Drexel UniversityLindsay Steele - Drexel UniversityTirth Patel - Drexel UniversityAhmad Rai - Drexel UniversityMenahem Y. Rotenberg - Ben-Gurion University of the NegevKimberly Wasko - Drexel UniversityAndrew R. Kohut - Drexel UniversityRichard Sensenig - University of PennsylvaniaGary Friedman - Drexel University
- Publication Details
- ACS nano, v 10(10), pp 9559-9569
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 11
- Grant note
- Drexel University College of Medicine Clinical & Translational Research Institute (CTRL) R01HL107771 / National Heart, Lung, and Blood Institute Award Office of Research, Drexel University (IVIS grant) H1504 / W.W. Smith Charitable Trust Award Commonwealth of Pennsylvania Universal Research Enhancement (CURE) grant
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; School of Biomedical Engineering, Science, and Health Systems; Surgery
- Web of Science ID
- WOS:000386423600057
- Scopus ID
- 2-s2.0-84994056003
- Other Identifier
- 991019168521904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology