Journal article
Magnetic resonance imaging-based partial volume-corrected F-18-sodium fluoride positron emission tomography in the femoral neck
Nuclear medicine communications, v 42(4), pp 416-420
01 Apr 2021
PMID: 33306627
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives
F-18-sodium fluoride (NaF) is a radiotracer used in PET that reflects calcium metabolism and osteoblastic activity. In this study, we assessed the construct validity of a novel application of global assessment to measure NaF uptake in the femoral neck as a method of evaluating physiologic changes in osteoblastic metabolism with age.
Methods
Whole-body NaF-PET/computed tomography (CT) images and MRI of 24 male patients with a history of nonmetastatic prostate cancer between the ages of 36 and 82 years (67.8 +/- 9.6) were analyzed. A region of interest delineated the entire femoral neck on the PET/CT image to determine the mean standardized uptake value (SUVmean). Correction for the partial volume effect was performed by measuring the volume of inert yellow bone marrow by MRI segmentation. Multiple linear regression was used to assess the relationship of uptake with age and body weight.
Results
The SUVmean with and without partial volume correction decreased with respect to age (P = 0.001 and P = 0.002, respectively). Body weight was not significantly related to any measured PET parameter.
Conclusion
Our results support the use of global NaF uptake with magnetic resonance-derived partial volume correction in the femoral neck. Because osteoblastic metabolism is known to decrease with normal aging, the observed decrease in NaF uptake constitutes evidence for convergent validity, indicating that the proposed methodology likely reflects systemic osteoblastic activity. Future studies of this methodology are warranted in other instances of varying osteoblastic activity such as in metabolic bone diseases and for the evaluation of therapy targeting osteoblastic metabolism.
Metrics
Details
- Title
- Magnetic resonance imaging-based partial volume-corrected F-18-sodium fluoride positron emission tomography in the femoral neck
- Creators
- Cyrus Ayubcha - Hospital of the University of PennsylvaniaWilliam Y. Raynor - Drexel UniversityAustin J. Borja - Hospital of the University of PennsylvaniaSiavash M. Seraj - Hospital of the University of PennsylvaniaChaitanya Rojulpote - Hospital of the University of PennsylvaniaThomas J. Werner - Hospital of the University of PennsylvaniaMona-Elisabeth Revheim - Oslo University HospitalChamith S. Rajapakse - Hospital of the University of PennsylvaniaAbass Alavi - Hospital of the University of Pennsylvania
- Publication Details
- Nuclear medicine communications, v 42(4), pp 416-420
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000639304900010
- Scopus ID
- 2-s2.0-85102911287
- Other Identifier
- 991019350582904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging