Journal article
Magnetic resonance imaging response in patients treated with definitive radiation therapy for medically inoperable endometrial cancer—Does it predict treatment response?
Brachytherapy, v 18(4), pp 437-444
Jul 2019
PMID: 31005602
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many patients with endometrial cancer cannot undergo surgery and instead receive definitive radiation therapy (RT). We investigate the correlation between MRI response to RT and clinical outcomes.
Women with inoperable, clinical Stage I endometrial cancer were treated with definitive brachytherapy (BT) with/without pelvic RT (PRT). Patients underwent MRI with functional diffusion-weighted imaging before and after RT. A radiologist retrospectively classified cases as complete, partial, or indeterminate response (CR, PR, or IR, respectively) vs. disease progression. Local control was clinicopathologically defined.
From 2007 to 2017, 50 women underwent definitive RT. Thirty-five (70%) received BT alone (median dose 37.5 Gy). For combined therapy, the median PRT and BT doses were 45 and 25 Gy, respectively. Median gross tumor volume and high-risk clinical target volume were 7.1 cc and 90.0 cc, respectively. Median followup among living patients was 20 months. All patients underwent post-RT MRI with T1/T2 sequencing at a median of 3.2 months after RT; 40 patients (80%) underwent functional diffusion-weighted imaging sequences. On initial post-RT MRI, CR was documented in 42 patients (84%), IR in 1 patient (2%), and PR in seven patients (14%). At median followup of 16.3 months, no CR patients had uterine failure. Among eight patients with initial PR/IR, all were found to be clinicopathologically no evidence of disease at the uterus on further evaluation.
Definitive RT with BT or BT + PRT is associated with high response rates on MRI. Overall, initial CR predicted for excellent outcome with no infield failure.
Metrics
Details
- Title
- Magnetic resonance imaging response in patients treated with definitive radiation therapy for medically inoperable endometrial cancer—Does it predict treatment response?
- Creators
- Brian J. Gebhardt - UPMC Hillman Cancer CenterBalasubramanya Rangaswamy - University of PittsburghJoel Thomas - University of PittsburghJoseph Kelley - University of PittsburghPaniti Sukumvanich - University of PittsburghRobert Edwards - University of PittsburghJohn Comerci - University of PittsburghAlexander Olawaiye - University of PittsburghMadeleine Courtney-Brooks - University of PittsburghMichelle Boisen - University of PittsburghJessica Berger - University of PittsburghSushil Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 18(4), pp 437-444
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000476854200002
- Scopus ID
- 2-s2.0-85064315707
- Other Identifier
- 991021897363804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging