Journal article
Magnetic separation of immobilized biocatalyst enables continuous manufacturing with a solids-forming reaction
Reaction chemistry & engineering, v 8(9), pp 2323-2331
22 Aug 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
End-to-end continuous manufacturing often provides improvements to product quality control and process economics over traditional batch processes. Design of new continuous unit operations for product isolation and catalyst recovery is necessary for realization of fully continuous processes involving difficult or coupled chemistries and separations. In this work, a magnetic separation technique is designed and applied to separate biofunctionalized catalyst particles from crystalline product in a continuous process to yield a high-purity product stream and continuously recycle catalyst to a reactor. A separator was created to recover and recycle >99.9% of catalyst in a continuous reactive crystallizer. The separator is demonstrated for enzymatic synthesis of amoxicillin, yielding pure amoxicillin trihydrate with a volumetric productivity of >250 g L-1 per day. Magnetic separation systems are envisioned to enable other continuous, heterogeneously catalyzed, solids-forming reactions.
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Details
- Title
- Magnetic separation of immobilized biocatalyst enables continuous manufacturing with a solids-forming reaction
- Creators
- Colton E. E. Lagerman - Georgia Institute of TechnologyGrant D. D. Marshall - Georgia Institute of TechnologyMatthew A. A. McDonald - Georgia Institute of TechnologyPatrick R. R. Harris - Georgia Institute of TechnologyMartha A. A. Grover - Georgia Institute of TechnologyRonald W. W. Rousseau - Georgia Institute of TechnologyAndreas S. S. Bommarius - Georgia Institute of Technology
- Publication Details
- Reaction chemistry & engineering, v 8(9), pp 2323-2331
- Publisher
- Royal Soc Chemistry
- Number of pages
- 9
- Grant note
- U01FD006484 / U.S. Food and Drug Administration Center for Drug Evaluation and Research DGE-1650044 / U.S National Science Foundation through the Graduate Research Fellowship Program (GRFP)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:001002333600001
- Scopus ID
- 2-s2.0-85163316569
- Other Identifier
- 991021958106204721
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- Web of Science research areas
- Chemistry, Multidisciplinary
- Engineering, Chemical