Journal article
Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway
American Journal of Physiology: Cell Physiology, v 282(6), pp C1387-C1395
01 Jun 2002
PMID: 11997253
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, the role of the calcineurin pathway in skeletal muscle atrophy and atrophy-reducing interventions was investigated in rat soleus muscles. Because calcineurin has been suggested to be involved in skeletal and cardiac muscle hypertrophy, we hypothesized that blocking calcineurin activity would eliminate beneficial effects of interventions that maintain muscle mass in the face of atrophy-inducing stimuli. Hindlimb suspension and spinal cord transection were used to induce atrophy, and intermittent reloading and exercise were used to reduce atrophy. Cyclosporin (CsA, 25 mg · kg−1 · day−1) was administered to block calcineurin activity. Soleus muscles were studied 14 days after the onset of atrophy. CsA administration did not inhibit the beneficial effects of the two muscle-maintaining interventions, nor did it change muscle mass in control or atrophied muscles, suggesting that calcineurin does not play a role in regulating muscle size during atrophy. However, calcineurin abundance was increased in atrophied soleus muscles, and this was associated with nuclear localization of NFATc1 (a nuclear factor of activated T cells). Therefore, results suggest that calcineurin may be playing opposing roles during skeletal muscle atrophy and under muscle mass-maintaining conditions.
Metrics
Details
- Title
- Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway
- Creators
- Esther E Dupont-Versteegden - Departments of Geriatrics andMicheal Knox - Departments of Geriatrics andCathy M Gurley - Departments of Geriatrics andJohn D Houlé - Anatomy and Neurobiology, University of Arkansas for Medical Sciences, andCharlotte A Peterson - Departments of Geriatrics and, Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205
- Publication Details
- American Journal of Physiology: Cell Physiology, v 282(6), pp C1387-C1395
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000175441600022
- Scopus ID
- 2-s2.0-0036080489
- Other Identifier
- 991014877807704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Physiology