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Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity
Journal article   Peer reviewed

Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity

Rohit Bhargava, Sushil Beriwal and David J Dabbs
American journal of clinical pathology, v 127(1), pp 103-113
Jan 2007
DOI: https://doi.org/10.1309/TDP92PQLDE2HLEET
PMID: 17145637
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1309/TDP92PQLDE2HLEETView
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Abstract

Biomarkers, Tumor - analysis Breast Neoplasms - chemistry Breast Neoplasms - pathology Carrier Proteins - analysis Female Glycoproteins - analysis Humans Immunohistochemistry Mammaglobin A Microarray Analysis Neoplasm Proteins - analysis Neoplasms - chemistry Sensitivity and Specificity Uteroglobin - analysis
There are limited data that compare the usefulness of mammaglobin with gross cystic disease fluid protein-15 (GCDFP-15) in the identification of breast carcinomas. Whole tissue sections of 29 breast carcinomas with matched lymph node metastases and 63 breast carcinomas on tissue microarray were stained with mammaglobin cocktail and GCDFP-15 antibodies. In addition, tissue microarrays (US Biomax, Rockville, MD) containing 544 different human tumors were also stained with the mammaglobin antibody cocktail. Positive staining was seen in 67 (55.4%) of 121 breast carcinomas with mammaglobin and in 28 cases (23.1%) with GCDFP-15. In the majority of cases, the staining intensity and number of cells staining were higher with mammaglobin than with GCDFP-15. Positive mammaglobin staining was also seen in 44 (8.1%) of 544 nonbreast tumors. Mammaglobin is a more sensitive marker than GCDFP-15 for breast carcinoma; however, it lacks the specificity of GCDFP-15.

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Pathology
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