Journal article
MammoSite ® accelerated partial breast irradiation: A single-institution outcomes analysis with 2 years of followup
Brachytherapy, v 8(1), pp 9-13
2009
PMID: 18955020
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To provide longitudinal follow-up and assess the intermediate outcomes in breast cancer patients treated with the MammoSite
® radiation therapy system.
Ninety-two patients with histologically proven stage 0-II breast cancer were treated with MammoSite
® accelerated partial breast irradiation after breast-conserving surgery. The catheter was placed at the time of surgery or postoperatively. Treatment prescription was 3.4
Gy b.i.d. for a period of five days using high-dose-rate afterloading. Clinical and dosimetric parameters including dose to 90% of PTV, volume of PTV receiving 100% of dose, volume of PTV receiving 150% of dose, edited PTV, and dose homogeneity index were analyzed as variables correlating with late effects.
All patients received the prescribed treatment. Seventy-seven percent of patients had intraoperative catheter placement, which was associated with a higher rate of persistent seroma (79%). The presence of seroma did not affect cosmesis. Ten patients developed telangiectasia at a median of 20.5 months. Skin dose and balloon-to-skin distance had a significant correlation with the development of telangiectasia that significantly affected cosmetic grading. The telangiectasia incidence for maximum skin dose of >100% and >125% of the prescription dose were 28% and 63%, compared with 0% (
p
=
0.0001) and 4.2% (
p
=
0.0001) for doses of ≤100% and ≤125%, respectively. Overall, most patients had excellent cosmetic results, and local control of disease was excellent.
MammoSite
® radiation therapy system demonstrates excellent local control and cosmetic outcome with extended followup. The maximum skin dose should be kept below 100% to reduce late effects on skin and improve cosmetic outcome. The persistence of seroma is higher with intraoperative placement of the catheter, and therefore postoperative placement is preferred.
Metrics
Details
- Title
- MammoSite ® accelerated partial breast irradiation: A single-institution outcomes analysis with 2 years of followup
- Creators
- Marsha Haley - Magee-Womens HospitalSushil Beriwal - Magee-Womens HospitalDwight E. Heron - Magee-Womens HospitalHayeon Kim - Magee-Womens HospitalJeffrey Falk - Magee-Womens HospitalRonald Johnson - Magee-Womens HospitalRobert Mogus - Magee-Womens Hospital
- Publication Details
- Brachytherapy, v 8(1), pp 9-13
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000263454700005
- Scopus ID
- 2-s2.0-58149508024
- Other Identifier
- 991021897380104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging