Journal article
Management of Nodal Disease in Advanced Cervical Cancer
Seminars in radiation oncology, v 29(2), pp 158-165
Apr 2019
PMID: 30827454
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During the last decade the adoption of image-guided adaptive brachytherapy has dramatically improved local control in patients with locally advanced cervical cancer (LACC) treated with radiotherapy and concomitant chemotherapy; however, nodal failure remains an obstacle. Metastatic lymph nodes can be detected by surgical and imaging approaches with different sensitivities and specificities, that improve the definition of relevant targets for macroscopic and microscopic nodal disease, and that influence our understanding of dose levels of external beam radiotherapy. Systematic use of modern radiotherapy techniques including intensity modulated radiotherapy and simultaneously integrated nodal boosts in combination with daily position verification is emerging as increasingly important for obtaining nodal control in LACC. This review summarizes published and ongoing efforts for optimizing nodal disease treatment in LACC, elaborates the state of the art approach for nodal disease detection, radiotherapy planning and delivery, and discusses future investigational efforts needed for precise optimization.
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Details
- Title
- Management of Nodal Disease in Advanced Cervical Cancer
- Creators
- Ina-Maria Jürgenliemk-Schulz - University Medical Center UtrechtSushil Beriwal - UPMC Hillman Cancer CenterAstrid A.C. de Leeuw - University Medical Center UtrechtJacob Christian Lindegaard - Aarhus University HospitalChristel Nadine Nomden - University Medical Center UtrechtRichard Pötter - Medical University of ViennaKari Tanderup - Aarhus University HospitalAkila N. Viswanathan - Johns Hopkins MedicineBeth Erickson - Medical College of Wisconsin
- Publication Details
- Seminars in radiation oncology, v 29(2), pp 158-165
- Publisher
- Elsevier
- Grant note
- Varian Medical Systems (http://dx.doi.org/10.13039/100007210) Elekta (http://dx.doi.org/10.13039/100011676)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000462554900009
- Scopus ID
- 2-s2.0-85059326461
- Other Identifier
- 991021897385104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging