Journal article
Managing Neurological Complications in Pediatric Diabetic Ketoacidosis: Insights from Low-Resource Emergency Departments and Comparisons with High-Resource Settings: A Narrative Review
Current treatment options in pediatrics, v 11(1), 14
01 Dec 2025
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Abstract
Purpose of Review
Pediatric diabetic ketoacidosis (DKA) poses significant risks, including severe neurological complications such as cerebral edema, which impacts mortality and long-term outcomes. Disparities in management between low-resource and high-resource settings highlight differences in treatment protocols and patient outcomes. This review aims to compare the management of pediatric DKA and associated neurological complications between low-resource and high-resource settings and to identify strategies to improve outcomes in diverse healthcare environments.
Recent Findings
A widespread search was conducted using databases PubMed, Scopus, Web of Science, and Google Scholar for studies from January 2010 to June 2024 with these keywords: diabetic ketoacidosis (DKA); pediatric; cerebral edema; neurologic complications; management protocols. Inclusion criteria focused on English-language studies on DKA management and neurological outcomes in pediatric populations. Both low-resource and high-resource settings were analyzed. Effective management of pediatric DKA requires early intervention and adherence to protocols. Disparities between settings necessitate further research on cost-effective solutions and implementation strategies to improve care globally.
Summary
High-resource settings benefit from advanced diagnostics, continuous insulin infusion, and specialized care, resulting in lower mortality and better outcomes. Conversely, low-resource settings face higher mortality due to limited resources, less frequent monitoring, and less aggressive treatment protocols. Innovations like point-of-care ultrasound and telemedicine show promise in bridging these gaps.
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Details
- Title
- Managing Neurological Complications in Pediatric Diabetic Ketoacidosis: Insights from Low-Resource Emergency Departments and Comparisons with High-Resource Settings: A Narrative Review
- Creators
- Marina Ramzy Mourid - Alexandria UniversityVictor N. Oboli - Yale UniversityPaviter Gill - Harbin Medical UniversityReshma Pyala (Corresponding Author) - Medical University of LublinSyeda AlishahZehra - Civil Hospital KarachiLuis L Gamboa - Drexel UniversityMohammed Alsabri - St. Christopher's Hospital for Children
- Publication Details
- Current treatment options in pediatrics, v 11(1), 14
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Emergency Medicine
- Scopus ID
- 2-s2.0-105007775737
- Other Identifier
- 991022055078704721