Journal article
Mandibular Movement Analysis to Assess Efficacy of Oral Appliance Therapy in OSA
Chest, v 154(6), pp 1340-1347
Dec 2018
PMID: 30413243
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The respiratory effort index derived from vertical mandibular movements (MM-REI) is a potential marker of increased respiratory effort during sleep. We evaluated the effectiveness of mandibular advancement splint therapy using MM-REI, in comparison with the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI).
Fifty-six subjects (median age, 47 years) with OSA treated with a custom mandibular advancement splint (Herbst appliance) were evaluated at the end of the titration procedure when snoring was reported absent by the sleep partner. We employed a magnetometer to capture mandibular movements (Brizzy; Nomics). Mandibular advancement splint efficacy was assessed as the percent change from baseline, using Bayesian multilevel models.
At the end of titration, all indices of OSA severity decreased compared with baseline: AHI (–48.9% to –71.1%), ODI (–49.5% to –77.2%), with obstructive hypopnea index and MM-REI showing the largest responses (–70.6% to –88.5% and –69.5% to –96.3%, respectively). MM-REI normalization via reductions in both mandibular movement event rate and duration accurately reflected efficacy of the appliance.
The reduction of vertical respiratory mandibular movements estimated by MM-REI and sleep respiratory effort duration accompanied the decrease in obstructive hypopneas, AHI, and ODI when snoring resolved in subjects with OSA treated with an optimally titrated mandibular advancement splint.
Metrics
Details
- Title
- Mandibular Movement Analysis to Assess Efficacy of Oral Appliance Therapy in OSA
- Creators
- Jean-Benoit Martinot - CHU Dinant Godinne UCL NamurNam N. Le-Dong - Research and Development, RespiSom, Erpent, BelgiumEtienne Crespeigne - Research and Development, RespiSom, Erpent, BelgiumPhilip E. Silkoff - Drexel UniversityValérie Cuthbert - Research and Development, RespiSom, Erpent, BelgiumStéphane Denison - Research and Development, RespiSom, Erpent, BelgiumJean-Christian Borel - Université Grenoble AlpesJean-Louis Pépin - Université Grenoble Alpes
- Publication Details
- Chest, v 154(6), pp 1340-1347
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000452776800024
- Scopus ID
- 2-s2.0-85058603879
- Other Identifier
- 991021881399104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Critical Care Medicine
- Respiratory System