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Journal article
Mannitol ingestion causes concentration-dependent, sex-biased mortality in adults of the fruit fly (Drosophila melanogaster)
PloS one, v 14(5), pp e0213760-e0213760
31 May 2019
PMID: 31150400
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mannitol, a sugar alcohol used in commercial food products, has been previously shown to induce sex-biased mortality in female Drosophila melanogaster when ingested at a single concentration (1 M). We hypothesized that sex differences in energy needs, related to reproductive costs, contributed to the increased mortality we observed in females compared to males. To test this, we compared the longevity of actively mating and non-mating flies fed increasing concentrations of mannitol. We also asked whether mannitol-induced mortality was concentration-dependent for both males and females, and if mannitol's sex-biased effects were consistent across concentrations. Females and males both showed concentration-dependent increases in mortality, but female mortality was consistently higher at concentrations of 0.75 M and above. Additionally, fly longevity decreased further for both sexes when housed in mixed sex vials as compared to single sex vials. This suggests that the increased energetic demands of mating and reproduction for both sexes increased the ingestion of mannitol. Finally, larvae raised on mannitol produced expected adult sex ratios, suggesting that sex-biased mortality due to the ingestion of mannitol occurs only in adults. We conclude that sex and reproductive status differences in mannitol ingestion drive sex-biased differences in adult fly mortality.
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Details
- Title
- Mannitol ingestion causes concentration-dependent, sex-biased mortality in adults of the fruit fly (Drosophila melanogaster)
- Creators
- Katherine Fiocca - Drexel UniversityMeghan Barrett - Drexel UniversityEdward A. Waddell - Drexel UniversityJennifer Viveiros - Drexel UniversityCheyenne McNair - Drexel UniversitySean O'Donnell - Drexel UniversityDaniel R. Marenda - Drexel University
- Publication Details
- PloS one, v 14(5), pp e0213760-e0213760
- Publisher
- Public Library Science
- Number of pages
- 16
- Grant note
- National Science Foundation; National Science Foundation (NSF) Drexel University Office of Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES); Biology
- Web of Science ID
- WOS:000469759100008
- Scopus ID
- 2-s2.0-85066448263
- Other Identifier
- 991019167795804721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology