Journal article
Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers
Journal of virology, v 76(7), pp 3502-3510
Apr 2002
PMID: 11884574
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV × C57BL/6)F
2
mice were generated and examined for their disease susceptibility in terms of clinical symptoms, ocular disease, and antibody production following corneal scarification with HSV (KOS). A genome-wide screen was carried out using microsatellite markers to determine the genetic loci involved in this response. Loci on chromosomes 4, 5, 12, 13, and 14 were shown to be involved in general susceptibility to clinical disease, whereas loci on chromosomes 10 and 17 were shown to be unique to ocular disease.
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Details
- Title
- Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers
- Creators
- Kazumi Norose - Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, JapanAkihiko Yano - Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, JapanXiang-Ming Zhang - Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, JapanElizabeth Blankenhorn - Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, JapanEllen Heber-Katz - Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, Japan
- Publication Details
- Journal of virology, v 76(7), pp 3502-3510
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000174330500042
- Scopus ID
- 2-s2.0-0036123128
- Other Identifier
- 991014877718904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Virology