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Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans Technical note
Journal article   Peer reviewed

Mapping of microstimulation evoked responses and unit activity patterns in the lateral hypothalamic area recorded in awake humans Technical note

W. Bryan Wilent, Michael Y. Oh, Catherine Buetefisch, Julian E. Bailes, Diane Cantella, Cindy Angle and Donald M. Whiting
Journal of neurosurgery, v 115(2)
01 Aug 2011
DOI: https://doi.org/10.3171/2011.3.JNS101574
PMID: 21495826
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Clinical Neurology Life Sciences & Biomedicine Neurosciences & Neurology Science & Technology Surgery
Major contributions to the understanding of human brain function have come from detailed clinical reports of responses evoked by electrical stimulation and specific brain regions during neurosurgical procedures in awake humans. In this study, microstimulation evoked responses and extracellular unit recordings were obtained intraoperatively in 3 awake patients undergoing bilateral implantation of deep brain stimulation electrodes in the lateral hypothalamus. The microstimulation evoked responses exhibited a clear anatomical distribution. Anxiety was most reliably evoked by stimulation directed ventromedially within or adjacent to the ventromedial nucleus of the hypothalamus, nausea was most reliably evoked by stimulation directed at the center of the lateral hypothalamus, and paresthesias were most reliably evoked by stimulation at the border of the lateral hypothalamus and basal nuclei. Regarding the unit recordings, the firing rates of individual neurons did not have an anatomical distribution, but a small subpopulation of neurons located at the border of the lateral hypothalamus and basal nuclei exhibited a fast rhythmically bursting behavior with an intraburst frequency of 200-400 Hz and an interburst frequency of 10-20 Hz. Based on animal studies, the lateral hypothalamic area and surrounding hypothalamic nuclei are putatively involved with a variety of physiological, behavioral, and sensory functions. The lateral hypothalamus is situated to play a dynamic and complex role in human behavior and this report further shows that to be true. In addition, this report should serve as a valuable resource for future intracranial work in which accurate targeting within this region is required. (DOI: 10.3171/2011.3.JNS101574)

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16 citations in Web of Science
17 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Surgery
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