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Journal article
Mapping the Parameter Space of tDCS and Cognitive Control via Manipulation of Current Polarity and Intensity
Frontiers in human neuroscience, v 10(2016), pp 665-665
27 Dec 2016
PMID: 28082886
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the cognitive domain, enormous variation in methodological approach prompts questions about the generalizability of behavioral findings obtained from studies of transcranial direct current stimulation (tDCS). To determine the impact of common variations in approach, we systematically manipulated two key stimulation parameters-current polarity and intensity-and assessed their impact on a task of inhibitory control (the Eriksen Flanker). Ninety participants were randomly assigned to one of nine experimental groups: three stimulation conditions (anode, sham, cathode) crossed with three intensity levels (1.0, 1.5, 2.0 mA). As participants performed the Flanker task, stimulation was applied over left dorsolateral prefrontal cortex (DLPFC; electrode montage: F3-RSO). The behavioral impact of these manipulations was examined using mixed effects linear regression. Results indicate a significant effect of stimulation condition (current polarity) on the magnitude of the interference effect during the Flanker; however, this effect was specific to the comparison between anodal and sham stimulation. Inhibitory control was therefore improved by anodal stimulation over the DLPFC. In the present experimental context, no reliable effect of stimulation intensity was observed, and we found no evidence that inhibitory control was impeded by cathodal stimulation. Continued exploration of the stimulation parameter space, particularly with more robustly powered sample sizes, is essential to facilitating cross-study comparison and ultimately working toward a reliable model of tDCS effects.
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Details
- Title
- Mapping the Parameter Space of tDCS and Cognitive Control via Manipulation of Current Polarity and Intensity
- Creators
- Elisabeth A. Karuza - University of PennsylvaniaZuzanna Z. Balewski - University of PennsylvaniaRoy H. Hamilton - University of PennsylvaniaJohn D. Medaglia - University of PennsylvaniaNathan Tardiff - University of PennsylvaniaSharon L. Thompson-Schill - University of Pennsylvania
- Publication Details
- Frontiers in human neuroscience, v 10(2016), pp 665-665
- Publisher
- Frontiers Media Sa
- Number of pages
- 9
- Grant note
- DC-009209-12 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DC009209 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000390751600001
- Scopus ID
- 2-s2.0-85009085068
- Other Identifier
- 991019296571804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Psychology