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Journal article
Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System
ACS nano
06 Aug 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanomedicine has long pursued the goal of targeted delivery to specific organs and cell types but has yet to achieve this goal with the vast majority of targets. One rare example of success in this pursuit has been the 25+ years of studies targeting the lung endothelium using nanoparticles conjugated to antibodies against endothelial surface molecules. However, here we show that such "endothelial-targeted" nanocarriers also effectively target the lungs' numerous marginated neutrophils, which reside in the pulmonary capillaries and patrol for pathogens. We show that marginated neutrophils' uptake of many of these "endothelial-targeted" nanocarriers is on par with endothelial uptake. This generalizes across diverse nanomaterials and targeting moieties and was even found with physicochemical lung tropism (i.e., without targeting moieties). Further, we observed this in ex vivo human lungs and in vivo healthy mice, with an increase in marginated neutrophil uptake of nanoparticles caused by local or distant inflammation. These findings have implications for nanomedicine development for lung diseases. These data also suggest that marginated neutrophils, especially in the lungs, should be considered a major part of the reticuloendothelial system (RES), with a special role in clearing nanoparticles that adhere to the lumenal surfaces of blood vessels.
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Details
- Title
- Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System
- Creators
- Marco E. Zamora - Drexel UniversityEno-Obong Essien - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaKartik Bhamidipati - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaAditi Murthy - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJing Liu - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaHyunjun Kim - Children's Hospital of PhiladelphiaManthan N. Patel - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJia Nong - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaZhicheng Wang - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaCarolann Espy - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaFatima N. Chaudhry - Children's Hospital of PhiladelphiaLaura T. Ferguson - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaSachchidanand Tiwari - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaElizabeth D. Hood - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaOscar A. Marcos-Contreras - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaSerena Omo-Lamai - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaTea Shuvaeva - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaEvguenia Arguiri - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJichuan Wu - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaLubica Rauova - Children's Hospital of PhiladelphiaMortimer Poncz - Children's Hospital of PhiladelphiaMaria C. Basil - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaEdward Cantu - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJoseph D. Planer - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaKara Spiller - Drexel UniversityJarod Zepp - Children's Hospital of PhiladelphiaVladimir R. Muzykantov - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJacob W. Myerson (Corresponding Author) - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJacob S. Brenner (Corresponding Author) - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
- Publication Details
- ACS nano
- Publisher
- AMER CHEMICAL SOC
- Number of pages
- 23
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001285537200001
- Scopus ID
- 2-s2.0-85200647532
- Other Identifier
- 991021897411804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology