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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Markers of B-Cell Activation in Relation to Risk of Non-Hodgkin Lymphoma
Cancer research (Chicago, Ill.), v 72(18), pp 4733-4743
30 Jul 2012
PMID: 22846913
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
B-cell activation biomarkers have been associated with increased risk of non-Hodgkin lymphoma (NHL) in HIV-infected populations. However, whether a similar association may exist in general populations has not been established. We conducted a case-control study within the Women’s Health Initiative Observational Study cohort to measure the B-cell activation biomarkers sCD23, sCD27, sCD30, sCD44, and CXCL13 in serum samples collected an average of 6 years before NHL diagnosis, in 491 cases and 491 controls. Using logistic regression to estimate odds ratios, we observed strong associations between NHL and markers, for all B-cell NHL and for major subtypes. Women with marker levels in the highest-versus-lowest quartile categories of CD23, CD27, CD30, or CXCL13 were at 2.8 to 5.5-fold increased risk of B-NHL. Additionally, there were significant trends of risk with increasing levels of these markers present. Associations were strongest for cases with shortest lag times between blood draw and diagnosis (<3 years). However, there were also significant associations for cases with the longest prediagnostic lag (9–13 years). Taken together, our findings indicate a prominent role for B-cell activation among postmenopausal women in the etiology of B-cell NHL and/or in processes reflective of early disease development, as early as 9 years before diagnosis.
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Details
- Title
- Markers of B-Cell Activation in Relation to Risk of Non-Hodgkin Lymphoma
- Creators
- Anneclaire J De Roos - Fred Hutch Cancer CenterDana K Mirick - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaKerstin L Edlefsen - University of WashingtonAndrea Z LaCroix - University of WashingtonKenneth J Kopecky - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaMargaret Madeleine - University of WashingtonLarry Magpantay - University of California at Los AngelesOtoniel Martínez-Maza - University of California at Los Angeles
- Publication Details
- Cancer research (Chicago, Ill.), v 72(18), pp 4733-4743
- Publisher
- American Association for Cancer Research (AACR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000309507900015
- Scopus ID
- 2-s2.0-84866421141
- Other Identifier
- 991020100076404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology