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Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the multi-ethnic study of atherosclerosis 384.90 kB
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Journal article
Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis
Environmental health perspectives, v 123(6), pp 541-548
01 Jun 2015
PMID: 25616153
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Toxicological research suggests that coarse particles (PM10-2.5) are inflammatory, but responses are complex and may be best summarized by multiple inflammatory markers. Few human studies have investigated associations with PM10-2.5 and, of those, none have explored long-term exposures. Here we examine long-term associations with inflammation and coagulation in the Multi-Ethnic Study of Atherosclerosis.
METHODS: Participants included 3,295 adults (45-84 years of age) from three metropolitan areas. Site-specific spatial models were used to estimate 5-year concentrations of PM10-2.5 mass and copper, zinc, phosphorus, silicon, and endotoxin found in PM10-2.5. Outcomes included interleukin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin-antiplasmin complex, and inflammation and coagulation scores. We used multivariable regression with multiply imputed data to estimate associations while controlling for potential confounders, including co-pollutants such as fine particulate matter.
RESULTS: Some limited evidence was found of relationships between inflammation and coagulation and PM10-2.5. Endotoxin was the PM10-2.5 component most strongly associated with inflammation, with an interquartile range (IQR) increase (0.08 EU/m(3)) associated with 0.15 (95% CI: 0.01, 0.28; p = 0.03) and 0.08 (95% CI: -0.07, 0.23; p = 0.28) higher inflammation scores before and after control for city, respectively. Copper was the component with the strongest association with coagulation, with a 4-ng/m(3) increase associated with 0.19 (95% CI: 0.08, 0.30; p = 0.0008) and 0.12 (95% CI: -0.05, 0.30; p = 0.16) unit higher coagulation scores before and after city adjustment, respectively.
CONCLUSIONS: Our cross-sectional analysis provided some evidence that long-term PM10-2.5 exposure was associated with inflammation and coagulation, but associations were modest and depended on particle composition.
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Details
- Title
- Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis
- Creators
- Sara D. Adar - University of MichiganJennifer D'Souza - University of MichiganKari Mendelsohn-Victor - University of MichiganDavid R. Jacobs - University of MinnesotaMary Cushman - University of VermontLianne Sheppard - University of WashingtonPeter S. Thorne - University of IowaGregory L. Burke - Wake Forest UniversityMartha L. Daviglus - Northwestern UniversityAdam A. Szpiro - University of WashingtonAna V. Diez Roux - University of MichiganJoel D. Kaufman - University of WashingtonTimothy V. Larson - University of Washington
- Publication Details
- Environmental health perspectives, v 123(6), pp 541-548
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 8
- Grant note
- P30 ES005605; P30-ES07033; K24 ES013195 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K24ES013195 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) RD833741010; RD83169701 / U.S. Environmental Protection Agency (EPA); United States Environmental Protection Agency R44HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01-HC-95159; N01-HC-95169 / National Heart, Lung, and Blood Institute/ National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U.S. EPA; United States Environmental Protection Agency N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000357296200014
- Scopus ID
- 2-s2.0-84930514771
- Other Identifier
- 991020111974404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology