Journal article
Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma: A work in progress
Neuro-oncology advances, v 6(1), 109
01 Jan 2024
PMID: 39036438
Abstract
Choroid plexus carcinomas (CPC) are early childhood cancers characterized by loss of TP53 function and poor survival. We are analyzing data on TP53 status, survival, and second cancers from the largest cohort of CPC receiving chemotherapy followed by consolidation with marrow-ablative chemotherapy (HDCx). Additionally, we discuss the rationale for targeted therapies for CPC patients. Currently, 8 of the 13 with Li-Fraumeni Syndrome-associated CPC were treated and continued CPC-free, indicating that HDCx improves CPC-free survival in young children with TP53-mutated CPC. These data justify the inclusion of HDCx in the planned prospective international trial for children with TP53-mutated CPC.
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Details
- Title
- Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma: A work in progress
- Creators
- Maxim Yankelevich - St Cristophers Hosp Children, Div Oncol, Philadelphia, PA USAWafik Zaky - The University of Texas MD Anderson Cancer CenterLucie Lafay-Cousin - Alberta Children's HospitalDiana Osorio - The University of Texas MD Anderson Cancer CenterJenny Adamski - Birmingham Women’s and Children’s NHS Foundation TrustUwe Kordes - Universität HamburgJonathan L. Finlay (Corresponding Author) - The Ohio State UniversityMichael Prados - University of California, San FranciscoSabine Mueller - University of California, San Francisco
- Publication Details
- Neuro-oncology advances, v 6(1), 109
- Publisher
- Oxford University Press
- Number of pages
- 6
- Grant note
- Jamie Wyss of the Wyss Soccer for Hope Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Hematology and Oncology
- Web of Science ID
- WOS:001272555500001
- Scopus ID
- 2-s2.0-85199360621
- Other Identifier
- 991022202503604721