Journal article
Maskless fabrication of cell-laden microfluidic chips with localized surface functionalization for the co-culture of cancer cells
Biofabrication, v 7(1), pp 015012-015012
01 Mar 2015
PMID: 25727298
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The utilization of the microfabrication technique to fabricate advanced computing chips has exponentially increased in the last few decades. Needless to say, this fabrication technique offers some unique advantages to develop micro-systems. Though many conventional microfabrication techniques today uses very harsh chemicals, the authors believe that the manipulation of system components and fabrication methods may aid in the utilization of the microfabrication techniques used in fabricating computer chips to develop advanced biological microfluidic systems. Presented in this paper is a fabrication approach in which popular fabrication methods and techniques are coupled together to develop an integrated system that aids in the fabrication of cell-laden microfluidic systems. This system aims to reduce the uses of harsh chemicals and decreases the lengthy fabrication time. Additionally, this integrated system will enable the printing of cells as the microfluidic chip is being fabricated. To demonstrate the unique capabilities of the integrated system, an advanced microfluidic chip is being fabricated and investigated. The advanced chip will feature the investigation of cancer cells in a co-cultured microfluidic environment. The investigations presented demonstrate cocultures in a microfluidic chip, advanced cell printing with localized surface enhancement, cell integration, and full additive fabrication of a microfluidic chip.
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Details
- Title
- Maskless fabrication of cell-laden microfluidic chips with localized surface functionalization for the co-culture of cancer cells
- Creators
- Qudus Hamid - Drexel UniversityChengyang Wang - Drexel UniversityJessica Snyder - Drexel UniversityShannon Williams - Drexel UniversityYigong Liu - Drexel UniversityWei Sun - Drexel University
- Publication Details
- Biofabrication, v 7(1), pp 015012-015012
- Publisher
- Iop Publishing Ltd
- Number of pages
- 13
- Grant note
- NSF-CMMI-1030520 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000353341000013
- Scopus ID
- 2-s2.0-84924310041
- Other Identifier
- 991019167541804721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials