Journal article
Maternal Dietary Patterns During Pregnancy and Child Autism-Related Traits in the Environmental Influences on Child Health Outcomes Consortium
Nutrients, v 16(22), 3802
06 Nov 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined relationships between prenatal dietary patterns and child autism-related outcomes, including parent-reported clinician diagnoses of autism spectrum disorder (ASD) and Social Responsiveness Scale (SRS-2) scores, in up to 6084 participants (with analytic samples ranging from 1671 to 4128 participants) from 14 cohorts in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Associations between quartiles of the Healthy Eating Index (HEI-2015), the Alternative Healthy Eating Index modified for Pregnancy (AHEI-P), and the Empirical Dietary Inflammatory Pattern (EDIP), calculated based on reported prenatal diet, and outcomes were examined using crude and multivariable regression (quantile for SRS scores and logistic for diagnosis). In adjusted models, the higher quartile of prenatal HEI score was associated with lower SRS scores (Q4 vs. Q1 β for median quantile = −3.41 95% CI = −5.15, −1.26). A similar association was observed for the AHEI-P score when adjusting for total calories (Q4 vs. Q1 β = −2.52 95% −4.59, −0.45). There were no significant associations of prenatal diet with ASD diagnosis. Findings from this large U.S.-based study do not suggest strong associations between prenatal dietary patterns and ASD-related outcomes, although subtle associations with broader traits suggest the need to further consider how prenatal diet may relate to ASD-related phenotypes.
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Details
- Title
- Maternal Dietary Patterns During Pregnancy and Child Autism-Related Traits in the Environmental Influences on Child Health Outcomes Consortium
- Creators
- Rachel Vecchione - Drexel UniversityMatt Westlake - RTI InternationalMegan G. Bragg - Drexel UniversityJuliette Rando - Drexel UniversityDeborah H. Bennett - University of California, DavisLisa A. Croen - Kaiser PermanenteAnne L. Dunlop - Emory UniversityAssiamira Ferrara - Kaiser PermanenteMonique M. Hedderson - Kaiser PermanenteJean M. Kerver - Michigan State UniversityBrian K. Lee - Drexel UniversityPi-I D. LinIrva Hertz-Picciotto - University of California, DavisRebecca J. Schmidt - University of California, DavisRita S. Strakovsky - Michigan State UniversityKristen Lyall - Drexel University
- Publication Details
- Nutrients, v 16(22), 3802
- Publisher
- MDPI
- Number of pages
- 16
- Grant note
- Office of the Director, National Institutes of Health: U2COD023375, U24OD023382, U24OD023319 Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health: U24OD035523, ES0266542, U24ES026539, U2CES026533, U2CES026542, U2CES030859, U2CES030857, U2CES026555, U2CES026561, U2CES030851, UG3/UH3OD023251, UH3OD023320, UG3OD035546, UH3OD023332, UG3/UH3OD023253, UG3/UH3OD023248, UG3OD035526, UG3/UH3OD023313, UH3OD023328, UH3OD023318, UG3/UH3OD023279, UG3/UH3OD023289, UG3/UH3OD023282, UH3OD023287, UG3/UH3OD023365, UG3/UH3OD023244, UG3/UH3OD023275, UH3OD023271, UG3OD035528, UH3OD023347, UG3/UH3OD023389, UG3/UH3OD023344, UH3OD023268, UG3/UH3OD023288, UG3/UH3OD023342, UG3/UH3OD023349, UH3OD023286, UG3OD035533, UG3/UH3OD023348, UG3/UH3OD023285, UG3/UH3OD023290, UG3/UH3OD023272, UG3/UH3OD023249, UG3/UH3OD023305, UG3/UH3OD023337, UG3OD035508, UG3OD035509, UG3OD035513, UG3OD035532, UG3OD035516, UG3OD035517, UG3OD035518, UG3OD035519, UG3OD035521, UG3OD035527, UG3OD035540, UG3OD035543, UG3OD035537, UG3OD035529, UG3OD035542, UG3OD035550, UG3OD035536, UG3OD035544 Office of Behavioral and Social Science ResearchNIHECHO Data Analysis Center
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (Measurement Core), U24OD035523 (Lab Core), ES0266542 (HHEAR), U24ES026539 (HHEAR Barbara O'Brien), U2CES026533 (HHEAR Lisa Peterson), U2CES026542 (HHEAR Patrick Parsons, Kannan Kurunthacalam), U2CES030859 (HHEAR Manish Arora), U2CES030857 (HHEAR Timothy R. Fennell, Susan J. Sumner, Xiuxia Du), U2CES026555 (HHEAR Susan L. Teitelbaum), U2CES026561 (HHEAR Robert O. Wright), U2CES030851 (HHEAR Heather M. Stapleton, P. Lee Ferguson), UG3/UH3OD023251 (Akram Alshawabkeh), UH3OD023320 and UG3OD035546 (Judy Aschner), UH3OD023332 (Clancy Blair, Leonardo Trasande), UG3/UH3OD023253 (Carlos Camargo), UG3/UH3OD023248 and UG3OD035526 (Dana Dabelea), UG3/UH3OD023313 (Daphne Koinis Mitchell), UH3OD023328 (Cristiane Duarte), UH3OD023318 (Anne Dunlop), UG3/UH3OD023279 (Amy Elliott), UG3/UH3OD023289 (Assiamira Ferrara), UG3/UH3OD023282 (James Gern), UH3OD023287 (Carrie Breton), UG3/UH3OD023365 (Irva Hertz-Picciotto), UG3/UH3OD023244 (Alison Hipwell), UG3/UH3OD023275 (Margaret Karagas), UH3OD023271 and UG3OD035528 (Catherine Karr), UH3OD023347 (Barry Lester), UG3/UH3OD023389 (Leslie Leve), UG3/UH3OD023344 (Debra MacKenzie), UH3OD023268 (Scott Weiss), UG3/UH3OD023288 (Cynthia McEvoy), UG3/UH3OD023342 (Kristen Lyall), UG3/UH3OD023349 (Thomas O'Connor), UH3OD023286 and UG3OD035533 (Emily Oken), UG3/UH3OD023348 (Mike O'Shea), UG3/UH3OD023285 (Jean Kerver), UG3/UH3OD023290 (Julie Herbstman), UG3/UH3OD023272 (Susan Schantz), UG3/UH3OD023249 (Joseph Stanford), UG3/UH3OD023305 (Leonardo Trasande), UG3/UH3OD023337 (Rosalind Wright), UG3OD035508 (Sheela Sathyanarayana), UG3OD035509 (Anne Marie Singh), UG3OD035513 and UG3OD035532 (Annemarie Stroustrup), UG3OD035516 and UG3OD035517 (Tina Hartert), UG3OD035518 (Jennifer Straughen), UG3OD035519 (Qi Zhao), UG3OD035521 (Katherine Rivera-Spoljaric), UG3OD035527 (Emily S Barrett), UG3OD035540 (Monique Marie Hedderson), UG3OD035543 (Kelly J Hunt), UG3OD035537 (Sunni L Mumford), UG3OD035529 (Hong-Ngoc Nguyen), UG3OD035542 (Hudson Santos), UG3OD035550 (Rebecca Schmidt), UG3OD035536 (Jonathan Slaughter), and UG3OD035544 (Kristina Whitworth). The sponsor, NIH, participated in the overall design and implementation of the ECHO program, which was funded as a cooperative agreement between NIH and grant awardees. The sponsor approved the Steering Committee-developed ECHO protocol and its amendments including COVID-19 measures. The sponsor had no access to the central database, which was housed at the ECHO Data Analysis Center. Data management and site monitoring were performed by the ECHO Data Analysis Center and Coordinating Center. All analyses for scientific publication were performed by the study statistician, independently of the sponsor. The lead author wrote all drafts of the manuscript and made revisions based on co-authors' and the ECHO Publication Committee's (a subcommittee of the ECHO Operations Committee) feedback without input from the sponsor. The study sponsor did not review or approve the manuscript for submission to this journal.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001365946200001
- Scopus ID
- 2-s2.0-85210937523
- Other Identifier
- 991021959914404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics