Journal article
Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes
International journal of environmental research and public health, v 19(18), 11332
09 Sep 2022
PMID: 36141604
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associations between arsenic and these phenotypic profiles, and evaluated whether folate status modified these associations. We identified three phenotypic profiles of neurodevelopment and three of anthropometry, ranging from less to more optimal child health. Gestational arsenic was associated with decreased odds of optimal neurodevelopment. Maternal folate status did not modify associations of arsenic with neurodevelopmental phenotypic profiles, but gestational arsenic was associated with increased odds of excess adiposity among those who exceed recommendations for folic acid (>1000 mu g/day). However, arsenic exposure was low and folate status was high. Gestational arsenic exposure may adversely impact child neurodevelopment and anthropometry, and maternal folate status may not modify these associations; however, future work should examine these associations in more arsenic-exposed or lower folate-status populations.
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Details
- Title
- Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes
- Creators
- Marisa A. Patti - Brown UniversityKarl T. Kelsey - Brown UniversityAmanda J. MacFarlane - Carleton UniversityGeorge D. Papandonatos - Brown UniversityTye E. Arbuckle - Health CanadaJillian Ashley-Martin - Health CanadaMandy Fisher - Health CanadaWilliam D. Fraser - Université de SherbrookeBruce P. Lanphear - Simon Fraser UniversityGina Muckle - Université LavalJoseph M. Braun - Brown University
- Publication Details
- International journal of environmental research and public health, v 19(18), 11332
- Publisher
- Mdpi
- Number of pages
- 19
- Grant note
- MOP-81285 / Health Canada A-Base R01 ES032386; R01 ES025214; R01 ES024381 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Canadian Institutes for Health Research; Canadian Institutes of Health Research (CIHR) Chemicals Management Plan at Health Canada Ontario Ministry of the Environment
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000856448900001
- Scopus ID
- 2-s2.0-85138424751
- Other Identifier
- 991022005071304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health