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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Maternal Infections during Pregnancy and Cerebral Palsy: A Population-based Cohort Study
Paediatric and perinatal epidemiology, v 27(6), pp 542-552
Nov 2013
PMID: 24117888
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundCerebral palsy (CP) is a common motor disability in childhood. We examined the association between maternal infections during pregnancy and the risk of congenital CP in the child.
MethodsLiveborn singletons in Denmark between 1997 and 2003 were identified from the Danish National Birth Registry and followed from 1 year of life until 2008. Redemption of antibiotics from the National Register of Medicinal Product Statistics and maternal infections reported by the National Hospital Register were used as markers of maternal infection during pregnancy. CP diagnoses were obtained from the Danish Cerebral Palsy Registry. Adjusted hazard ratio (HR) and 95% confidence interval (CI) were estimated by Cox proportional hazard models.
ResultsOf the 440564 singletons with follow-up data, 840 were diagnosed with congenital CP. Maternal genito-urinary tract infections (HR 2.1, 95% CI 1.4, 3.2) were associated with CP in all births, in term births (HR 1.9, 95% CI 1.1, 3.2), in children with spastic CP (HR 2.1, 95% CI 1.4, 3.3), and among first-born children (HR 1.9, 95% CI 1.4, 3.3). Overall, we found associations between redeemed nitrofurantoin (HR 1.7, 95% CI 1.1, 2.8) and CP. Among trimester-specific exposures, CP risk was associated with prescriptions redeemed in the first trimester for any antibacterials, beta-lactam antibacterials, and nitrofurantoin, an antibiotic commonly used to treat lower urinary tract infection, and genito-urinary tract infections in the third trimester.
ConclusionGenito-urinary tract infections and antibiotic use during pregnancy were associated with increased risks of CP, indicating that some maternal infections or causes of maternal infections present in prenatal life may be part of a causal pathway leading to CP.
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Details
- Title
- Maternal Infections during Pregnancy and Cerebral Palsy: A Population-based Cohort Study
- Creators
- Jessica E. Miller - University of California, Los AngelesLars Henning Pedersen - Aarhus UniversityElani Streja - University of California, Los AngelesBodil H. Bech - Aarhus UniversityMarshalyn Yeargin-Allsopp - Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USAKim Van Naarden Braun - Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USADiana E. Schendel - National Center on Birth Defects and Developmental DisabilitiesDeborah Christensen - National Center on Birth Defects and Developmental DisabilitiesPeter Uldall - University of Southern DenmarkJorn Olsen - Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
- Publication Details
- Paediatric and perinatal epidemiology, v 27(6), pp 542-552
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA University of Aarhus, Denmark
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000325983800005
- Scopus ID
- 2-s2.0-84886090894
- Other Identifier
- 991021229985704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics
- Public, Environmental & Occupational Health