Journal article
Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants
Journal of immunotoxicology, v 8(1), pp 95-100
Mar 2011
PMID: 21299357
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Animal data indicate that developmental tetrachlorodibenzo-p-dioxin exposure alters immune function; however, the potential immunotoxicity of dioxin-like and non-dioxin-like polychlorinated biphenyls (PCBs) in the developing infant is an understudied area. The aim of the current study is to examine the association between maternal and early postnatal PCB concentrations in relation to total infant serum immunoglobulin concentrations determined at 6-months-of-age. We selected 384 mother-infant pairs participating in a birth cohort study in Eastern Slovakia. PCB concentrations of several congeners were determined in maternal and cord serum samples and in infant serum samples collected at 6-months-of-age using gas chromatography with electron capture detection. Total immunoglobulin (Ig) G, A, and M concentrations were determined by nephelometry, and IgE concentrations were determined by enzyme-linked immunoassay. Linear regression models with adjustment for potential confounding factors were used to estimate the associations between maternal, cord, and 6-month infant PCB concentrations and total serum immunoglobulins. The median maternal serum concentration of PCB-153 was 140 ng/g lipid, 10-fold higher than concentrations in childbearing-age women in the United States during the same period. Maternal, cord, or 6-month infant PCB concentrations were not associated with total serum immunoglobulin levels at 6 months, regardless of the timing of PCB exposure, PCB congener, or specific immunoglobulin. In this population, which has high PCB concentrations relative to most populations in the world today, we did not observe any association between maternal and early postnatal PCB concentrations and total immunoglobulin measures of IgG, IgA, IgM, or IgE.
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Details
- Title
- Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants
- Creators
- Todd A. Jusko - National Institutes of HealthAnneclaire J. De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaStephen M. Schwartz - University of WashingtonB. Paige Lawrence - University of RochesterLubica Palkovicova - Slovak Medical UniversityTomas Nemessanyi - Slovak Medical UniversityBeata Drobna - Slovak Medical UniversityAnna Fabisikova - Slovak Medical UniversityAnton Kocan - Slovak Medical UniversityEva Jahnova - Slovak Medical UniversityTerrance J. Kavanagh - University of WashingtonTomas Trnovec - Slovak Medical UniversityIrva Hertz-Picciotto - University of California, Davis
- Publication Details
- Journal of immunotoxicology, v 8(1), pp 95-100
- Publisher
- Informa Healthcare
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000287043100011
- Scopus ID
- 2-s2.0-79751471352
- Other Identifier
- 991020099338704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Toxicology