Journal article
Maternal asthma and newborn DNA methylation
Clinical epigenetics, v 17(1), 79
10 May 2025
PMID: 40349045
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma.
To investigate the relationship between parental asthma and newborn blood DNA methylation.
Epigenome-wide association analyses were conducted in 13 cohorts on 7433 newborns with blood methylation data from the Illumina450K or EPIC array. We used fixed effects meta-analyses to identify differentially methylated CpGs (DMCs) and comb-p to identify differentially methylated regions (DMRs) associated with maternal asthma during pregnancy and maternal asthma ever. Paternal asthma was analyzed for comparison. Models were adjusted for covariates and cell-type composition. We examined whether implicated sites related to gene expression analyses in publicly available data for childhood blood and adult lung.
We identified 27 CpGs associated with maternal asthma during pregnancy at False Discovery Rate < 0.05 but none for maternal asthma ever. Two distinct CpGs were associated with paternal asthma. We observed 5 DMRs associated with maternal asthma during pregnancy 3 associated with maternal asthma ever and 13 DMRs associated with paternal asthma. Gene expression analysis using data in blood from 832 children and lung from 424 adults showed associations between identified DMCs using maternal asthma and expression of several genes, including HLA genes and HOXA5, previously implicated in asthma or lung function.
Parental asthma, especially maternal asthma during pregnancy, may be associated with alterations in newborn DNA methylation. These findings might shed light on underlying mechanisms for asthma susceptibility.
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Details
- Title
- Maternal asthma and newborn DNA methylation
- Creators
- Casper-Emil Tingskov Pedersen - University of CopenhagenThanh T Hoang - National Institute of Environmental Health SciencesJianping Jin - National Institute of Environmental Health SciencesAnna Starnawska - Aarhus UniversityRaquel Granell - University of BristolHannah R Elliott - University of BristolAnke Huels - Emory UniversityHeather J Zar - University of Cape TownDan J Stein - University of Cape TownYining Zhang - Emory UniversityHerman T den Dekker - Erasmus MCLiesbeth Duijts - Erasmus MCJanine F Felix - Erasmus MCJúlia Sangüesa - Barcelona Institute for Global HealthMariona Bustamante - Barcelona Institute for Global HealthMaribel Casas - Barcelona Institute for Global HealthMartine Vrijheid - Barcelona Institute for Global HealthLatha Kadalayil - University of SouthamptonFaisal I Rezwan - University of SouthamptonHasan Arshad - NIHR Southampton Biomedical Research CentreJohn W Holloway - University of SouthamptonStefan Röder - Helmholtz Centre for Environmental ResearchAna C Zenclussen - Helmholtz Centre for Environmental ResearchGunda Herberth - Helmholtz Centre for Environmental ResearchNicklas Heine Staunstrup - Aarhus UniversityHenriette Thisted Horsdal - Lundbeck FoundationJonathan Mill - University of ExeterEilis Hannon - University of ExeterIsabella Annesi-Maesano - InsermGiancarlo Pesce - InsermNour Baïz - InsermBarbara Heude - Université Paris CitéSahra Hosseinian-Mohazzab - University of Southern CaliforniaCarrie V Breton - University of Southern CaliforniaSophia Harlid - Umeå UniversityJustin Harbs - Umeå UniversityMagnus Domellof - Umeå UniversityChristina West - Umeå UniversityEdwina Yeung - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentXuehuo Zeng - GlotechWenche Nystad - Norwegian Institute of Public HealthSiri E Håberg - Norwegian Institute of Public HealthMaria C Magnus - University of BristolDiana Schendel - Lundbeck FoundationStephanie J London - National Institute of Environmental Health SciencesKlaus Bønnelykke - Copenhagen Prospective Studies on Asthma in ChildhoodiPSYCH-MINERvA Group
- Publication Details
- Clinical epigenetics, v 17(1), 79
- Publisher
- BMC
- Number of pages
- 14
- Grant note
- 0603-00280B / Strategiske Forskningsråd 903516 / The ministry of health, Denmark MC_UU_00011/5 / Medical Research Council and the University of Bristol 733206 / European Union's Horizon 2020 research and innovation programme 49019 / Intramural Research Program of the NIH R16-A1694 / Lundbeck Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001485659400001
- Scopus ID
- 2-s2.0-105004887387
- Other Identifier
- 991022053486304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity
- Oncology