Journal article
Maternal exposure to perfluorinated acids and fetal growth
Journal of exposure science & environmental epidemiology, v 20(7), pp 589-597
Nov 2010
PMID: 19865074
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The widespread detection of perfluorinated acids (PFAs) in humans and known developmental toxicity in animals has raised concern about their potential effects on human reproductive health. Our objective was to determine whether increasing maternal exposure to PFAs is associated with adverse effects on fetal growth and length of gestation in women giving birth in Alberta, Canada. We examined the concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonate (PFHxS) in a cohort of 252 pregnant women who gave birth to live singletons. Each of the women had undergone an early second trimester prenatal screen, and her serum was analyzed for PFA concentrations. Data on infant and maternal variables were collected from the delivery record completed at birth. Adjusted changes in birth weight per natural log (ng/ml) of PFOA (median 1.5 ng/ml), PFHxS (median 0.97 ng/ml), and PFOS (median 7.8 ng/ml) were -37.4 g (95% confidence interval (CI): -86.0 to 11.2 g), 21.9 g (-23.4 to 67.2 g), and 31.3 g (-43.3 to 105.9 g), respectively. Mean birth weight z-score, standardized for gestational age and gender, length of gestation, and risk of preterm birth did not appear to be influenced by maternal PFA exposure. When PFA concentrations were divided into tertiles, similar patterns were observed. These results suggest that maternal PFA exposure has no substantial effect on fetal weight and length of gestation at the concentrations observed in this population.
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Details
- Title
- Maternal exposure to perfluorinated acids and fetal growth
- Creators
- Michele P Hamm - Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, CanadaNicola M CherryEmily ChanJonathan W MartinIgor Burstyn
- Publication Details
- Journal of exposure science & environmental epidemiology, v 20(7), pp 589-597
- Publisher
- Springer Nature; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000283170400005
- Scopus ID
- 2-s2.0-77958485579
- Other Identifier
- 991014878124104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology