Journal article
Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders
Journal of autism and developmental disorders, v 40(12), pp 1423-1430
01 Dec 2010
PMID: 20414802
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Exposure to prenatal infection has been suggested to cause deficiencies in fetal neurodevelopment. In this study we included all children born in Denmark from 1980, through 2005. Diagnoses of autism spectrum disorders (ASDs) and maternal infection were obtained through nationwide registers. Data was analyzed using Cox proportional hazards regression. No association was found between any maternal infection and diagnosis of ASDs in the child when looking at the total period of pregnancy: adjusted hazard ratio = 1.14 (CI: 0.96-1.34). However, admission to hospital due to maternal viral infection in the first trimester and maternal bacterial infection in the second trimester were found to be associated with diagnosis of ASDs in the offspring, adjusted hazard ratio = 2.98 (CI: 1.29-7.15) and adjusted hazard ratio = 1.42 (CI: 1.08-1.87), respectively. Our results support prior hypotheses concerning early prenatal viral infection increasing the risk of ASDs.
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Details
- Title
- Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders
- Creators
- Hjördis O Atladóttir - Aarhus UniversityPoul Thorsen - AID AtlantaLars Østergaard - Aarhus University HospitalDiana E Schendel - National Center on Birth Defects and Developmental DisabilitiesSanne Lemcke - Aarhus UniversityMorsi Abdallah - Aarhus UniversityErik T Parner - Aarhus University
- Publication Details
- Journal of autism and developmental disorders, v 40(12), pp 1423-1430
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000284158200001
- Scopus ID
- 2-s2.0-78549271649
- Other Identifier
- 991021229881504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychology, Developmental