Journal article
Maternal medical and behavioral risk factors for congenital diaphragmatic hernia
Journal of pediatric surgery, v 49(1), pp 34-38
Jan 2014
PMID: 24439577
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Maternal factors contributing to the etiology of congenital diaphragmatic hernia (CDH) remain unclear. We hypothesized that specific maternal medical conditions (pregestational diabetes, hypertension), and behaviors (alcohol, tobacco) would be associated with CDH.
We conducted a population-based case–control study using Washington State birth certificates linked to hospital discharge records (1987–2009). We identified all infants with CDH (n=492). Controls were randomly selected among non-CDH infants. Maternal data were extracted from the birth record. Logistic regression was used to adjust for covariates.
Cases and controls were generally similar regarding demographics, although CDH infants were more likely to be male than controls (58.5% vs. 52.5%). Isolated and complex (multiple-anomaly) CDH had similar characteristics. Each of the exposures of interest was more common among case mothers than among control mothers. In univariate analysis, alcohol use, hypertension, and pregestational diabetes were each significantly associated with the outcome. After multivariate adjustment, only alcohol use (OR=3.65, p=0.01) and pregestational diabetes (OR=12.53, p=0.003) maintained significance. Results were similar for both isolated and complex CDH.
Maternal pregestational diabetes and alcohol use are significantly associated with occurrence of CDH in infants. These are important modifiable risk factors to consider with regard to efforts seeking to impact the incidence of CDH.
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Details
- Title
- Maternal medical and behavioral risk factors for congenital diaphragmatic hernia
- Creators
- Jarod P. McAteer - University of WashingtonAvram Hecht - University of California, San DiegoAnneclaire J. De Roos - Drexel UniversityAdam B. Goldin - University of Washington
- Publication Details
- Journal of pediatric surgery, v 49(1), pp 34-38
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000329849200006
- Scopus ID
- 2-s2.0-84892599840
- Other Identifier
- 991019168195304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Surgery