Journal article
Maternal obesity associated with inflammation in their children
World journal of pediatrics : WJP, v 8(1), 76
01 Feb 2012
PMID: 21874618
Abstract
Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-a, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI).
Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% Cl: 2-123).
Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight. World J Pediatr 2012;8(1):76-79
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Details
- Title
- Maternal obesity associated with inflammation in their children
- Creators
- Karen L. Leibowitz - Children's Hospital of PhiladelphiaRenee H. Moore - University of PennsylvaniaRexford S. Ahima - University of PennsylvaniaAlbert J. Stunkard - University of PennsylvaniaVirginia A. Stallings - Children's Hospital of PhiladelphiaRobert I. Berkowitz - Children's Hospital of PhiladelphiaJesse L. Chittams - University of PennsylvaniaMyles S. Faith - Children's Hospital of PhiladelphiaNicolas Stettler - Children's Hospital of Philadelphia
- Publication Details
- World journal of pediatrics : WJP, v 8(1), 76
- Publisher
- Zhejiang Univ Sch Medicine
- Number of pages
- 4
- Grant note
- UL1-RR-024134 / General Clinical Research Center/Clinical Translational Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30DK019525 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) DK 19525 / RIA/Biomarkers Core of the Pennsylvania Diabetes Center (NIH) DK 19525 / Institute for Diabetes, Obesity and Metabolism Unit (NIH) DK068899 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1RR024134 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) RR00240 / General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) Nutrition and Growth Laboratory of Children's Hospital of Philadelphia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000299916200014
- Scopus ID
- 2-s2.0-84859800685
- Other Identifier
- 991021448178804721
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