Journal article
Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors
Journal of reproductive immunology, v 77(2), pp 152-160
01 Apr 2008
PMID: 17692390
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Few studies have assessed longitudinal changes in circulating cytokine levels during normal pregnancy. We have examined the natural history of maternal plasma cytokines from early-to mid-pregnancy in a large, longitudinal cohort. Multiplex flow cytometry was used to measure interleukin (IL)-2, IL-6, IL-12, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) in early-(median [IQR]: 8.5 weeks [7.1, 10.0]) and mid-pregnancy (25.0 [24.1, 26.1]) from 1274 Danish women delivering singleton term infants. GM-CSF decreased from early-to mid-pregnancy (median percent change [95% CI]: -51.3% [-59.1%, -41.8%]), while increases were observed in IL-6 (24.3% [4.6%, 43.9%]), IL-12 (21.3% [8.9%, 35.7%]) and IFN-gamma (131.7% [100.2%, 171.6%]); IL-2 (-2.8% [-11.5%, 0.0%]) and TNF-alpha-(0% [-5.9%, 25.6%]) remained stable. Positive correlations were found between all cytokines, both in early-and mid-pregnancy (all p < 0.001). Early-and mid-pregnancy levels were rank-correlated for IL-2, IL-12, TNF-alpha and GM-CSF, but not IL-6 and IFN-gamma; these correlations were generally weaker than correlations between different cytokines at a single time point in pregnancy. Women with a pre-pregnancy BMI < 18.5 had reduced levels of IFN-gamma and GM-CSF compared to women in other BMI categories, while women aged >= 35 years had elevated IL-2, IL-6, TNF-alpha and IFN-gamma. Early-pregnancy levels of TNF-alpha-were higher in women with a prior preterm delivery. Cytokine levels were not associated with gravidity. In conclusion, cytokines were detected in plasma during early-and mid-pregnancy, with IL-6, IL-12, IFN-gamma and GM-CSF concentrations varying over pregnancy. Concentrations may depend on BMI, maternal age and prior preterm delivery. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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Details
- Title
- Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors
- Creators
- A. E. Curry - Emory UniversityI. Vogel - Aarhus UniversityK. Skogstrand - Aarhus UniversityC. Drews - Emory UniversityD. E. Schendel - National Center on Birth Defects and Developmental DisabilitiesW. D. Flanders - Emory UniversityD. M. Hougaard - Statens Serum InstitutP. Thorsen - Aarhus University
- Publication Details
- Journal of reproductive immunology, v 77(2), pp 152-160
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- UR3/CCU018305-03 / PHS HHS; United States Department of Health & Human Services; United States Public Health Service
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000255006200005
- Scopus ID
- 2-s2.0-40249100313
- Other Identifier
- 991021463550804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Reproductive Biology