Journal article
Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study
BJPsych open, v 2(2)
Mar 2016
PMID: 27703770
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.
To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability.
Using a register-based total population study (
=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD with and without intellectual disability in relation to lifetime diagnoses of maternal vitamin D deficiency. Although rare, such deficiency was associated with offspring risk of ASD with, but not without, intellectual disability (aORs 2.51, 95% CI 1.22-5.16 and 1.28, 0.68-2.42). Relationships were stronger in non-immigrant children.
If reflecting associations for prenatal hypovitaminosis, these findings imply gestational vitamin D substitution as a means of ASD prevention.
None.
© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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Details
- Title
- Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study
- Creators
- Cecilia Magnusson - , MD, PhDMichael Lundberg - , MPH, Department of Public Health Sciences, KarolinskaInstitutet, Stockholm, SwedenBrian K Lee - , PhD, Department of Epidemiology and Biostatistics, A.J. Drexel Autism Institute, Drexel University School of Public Health, Philadelphia, PA, USADheeraj Rai - , MRCPsych, PhD, Department of Public Health Sciences, KarolinskaInstitutet, Stockholm, Sweden; Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, UK; Avon and Wiltshire Partnership Mental Health NHS Trust, Bristol, UKHåkan Karlsson - , PhD, Department of Neuroscience, KarolinskaInstitutet, Stockholm, SwedenRenee Gardner - , PhD, Department of Public Health Sciences, KarolinskaInstitutet, Stockholm, SwedenKyriaki Kosidou - , MD, PhDStefan Arver - , MD, PhD, Department of Medicine, KarolinskaInstitutet, Stockholm, SwedenChristina Dalman - , MD, PhD, Department of Public Health Sciences, KarolinskaInstitutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Stockholm County Council, Solna, Sweden
- Publication Details
- BJPsych open, v 2(2)
- Publisher
- England
- Grant note
- R21 ES023760 / NIEHS NIH HHS 648916 / European Research Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000408510800010
- Scopus ID
- 2-s2.0-84986544129
- Other Identifier
- 991014878568904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry