Journal article
Mathematical modeling of the interaction between oxygen, nitric oxide and superoxide
Advances in experimental medicine and biology, v 645, pp 7-12
2009
PMID: 19227443
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Computer simulations were performed based on a multiple chemical species convection-diffusion model with coupled biochemical reactions for oxygen (O2), nitric oxide (NO), superoxide (O2*-), peroxynitrite (ONOO-), nitrite (NO2-) and nitrate (NO3-) in cylindrical geometry with blood flow through a 30 microm diameter arteriole. Steady state concentration gradients of all chemical species were predicted for different O2*- production rates, superoxide dismutase (SOD) concentrations, and blood flow rates. Effects of additional O2*- production from dysfunctional endothelial nitric oxide synthase (eNOS) were also simulated. The model predicts that convection is essential for characterizing O2 partial pressure gradients (PO2) in the bloodstream and surrounding tissue, but has little direct effect on NO gradients in blood and tissue.
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Details
- Title
- Mathematical modeling of the interaction between oxygen, nitric oxide and superoxide
- Creators
- Donald G Buerk - University of Pennsylvania
- Publication Details
- Advances in experimental medicine and biology, v 645, pp 7-12
- Publisher
- Springer Nature
- Grant note
- HL 068164 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000262627100002
- Scopus ID
- 2-s2.0-61849085205
- Other Identifier
- 9780387859989; 0387859985; 991019231723404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Physiology