Journal article
Maturational age affects pirenperone dose-response pattern
General pharmacology, v 18(3), 225
1987
PMID: 3569849
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
1.
1. The effects of the 5-HT
2 antagonist pirenperone on temperature preference were observed 1 hr after injection in mice aged 3, 5 and 7 days and at doses of 0.16, 0.48 and 1.6 mg/kg body weight.
2.
2. Although all 3 doses produced significant decreases in preferred temperature at 3 days, only the highest dose had significant effects at ages 5 and 7 days.
3.
3. Analysis of the data suggests that the dose-response relationship depends on age in a way that would be consistent with a shift in the dose-response curve with increasing age.
Metrics
Details
- Title
- Maturational age affects pirenperone dose-response pattern
- Creators
- Cecilie Goodrich - Cleveland State UniversityMichael Dillehay - Cleveland State University
- Publication Details
- General pharmacology, v 18(3), 225
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1987G910700003
- Scopus ID
- 2-s2.0-0023139884
- Other Identifier
- 991021229883604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy