Journal article
Meal Replacements in the Treatment of Adolescent Obesity: A Randomized Controlled Trial
Obesity (Silver Spring, Md.), v 19(6), pp 1193-1199
Jun 2011
PMID: 21151016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Use of meal replacements (MRs) in lifestyle modification programs (LMPs) for obese adults significantly increases weight loss, compared with prescription of an isocaloric conventional diet (CD). This 12-month randomized trial examined 113 obese adolescents (mean +/- s.d. age of 15.0 +/- 1.3 years and BMI of 37.1 +/- 5.1 kg/m(2)) who were assigned to a LMP, combined with meal plans of 1,300-1,500 kcal/day of CD (self-selected foods) or MR (three SlimFast shakes, one prepackaged meal, five vegetable/fruit servings). After month 4 (phase 1), participants originally treated with MR were unmasked to their phase 2 (months 5-12) random assignment: continued use of MR (i.e., MR+MR) or transitioned to CD (i.e., MR+CD). Participants initially treated with CD in phase 1, continued with CD (i.e., CD). All three groups were treated for an additional 8 months (phase 2). Regression models were used to evaluate percentage change in BMI from baseline to month 4 (phase 1), months 5-12 (phase 2), and baseline to month 12. At month 4, participants assigned to MR (N = 65) achieved a mean (+/-s.e.) 6.3 +/- 0.6% reduction in BMI, compared to a significantly (P = 0.01) smaller 3.8 +/- 0.8% for CD participants (N = 37). In phase 2, BMI increased significantly (P < 0.001) in all three conditions, resulting in no significant (P = 0.39) differences between groups in percentage change in BMI at month 12. Across groups, mean reduction in BMI from baseline to month 12 was 3.4 +/- 0.7% (P < 0.01). Use of MR significantly improved short-term weight loss, compared with CD, but its continued use did not improve maintenance of lost weight.
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Details
- Title
- Meal Replacements in the Treatment of Adolescent Obesity: A Randomized Controlled Trial
- Creators
- Robert I. Berkowitz - Children's Hospital of PhiladelphiaThomas A. Wadden - University of PennsylvaniaChristine A. Gehrman - Children's Hospital of PhiladelphiaChanelle T. Bishop-Gilyard - Children's Hospital of PhiladelphiaRenee H. Moore - University of PennsylvaniaLeslie G. Womble - University of PennsylvaniaJoanna L. Cronquist - Children's Hospital of PhiladelphiaNatalie L. Trumpikas - Children's Hospital of PhiladelphiaLorraine E. Levitt Katz - Children's Hospital of PhiladelphiaMelissa S. Xanthopoulos - Children's Hospital of Philadelphia
- Publication Details
- Obesity (Silver Spring, Md.), v 19(6), pp 1193-1199
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- UL1RR024134 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) DK054713; K24-DK065018 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DK054713 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000291021600013
- Scopus ID
- 2-s2.0-79957523339
- Other Identifier
- 991021448063204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics