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Measles immunization in HIV-infected children
Journal article   Peer reviewed

Measles immunization in HIV-infected children

N A Halsey, J S Abramson, P J Chesney, M C Fisher, M A Gerber, S M Marcy, D L Murray, G D Overturf, C G Prober, L B Weiner, …
Pediatrics (Evanston), v 103(5), pp 1057-1060
01 May 1999
PMID: 10224192

Abstract

Life Sciences & Biomedicine Pediatrics Science & Technology
Children infected with human immunodeficiency virus (HIV) have had high rates of mortality attributable to measles, but until recently, measles vaccine was assumed to be safe for these children. A single fatal case of pneumonia attributable to vaccine type-measles virus has been documented in a young adult with acquired immunodeficiency syndrome. Because a protective immune response often does not develop in severely immunocompromised HIV-infected patients after immunization and some risk of severe complications exists, HIV-infected children, adolescents, and young adults who are severely immunocompromised (based on age-specific CD4 lymphocyte enumeration) attributable to HIV infection should not receive measles vaccine, All other HIV-infected children, adolescents, and young adults who are not severely immunocompromised should receive measles-mumps-rubella vaccine.

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