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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Measurement of sodium ion concentration in undiluted urine with cation-selective polymeric membrane electrodes after the removal of interfering compounds
Talanta (Oxford), v 74(2), 255
30 Nov 2007
PMID: 18371638
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The measurement of sodium ion concentration in urine can provide diagnostic information and guide therapy. Unfortunately, neutral-carrier-based ion-selective electrodes show a large positive drift and loss in selectivity in undiluted urine. The extraction of electrically neutral lipids from the urine into the sensing membrane was suggested as the main source of the drift, loss of selectivity and the consequent incorrect concentration readings.
In this work, (i) solvent–solvent extraction, (ii) membrane-immobilized solvent extraction and (iii) solid phase extraction were used to remove interfering compounds from urine samples. The “cleaned” urine samples were subsequently analyzed using a calixarene (sodium ionophore X)-based, solid-contact, sodium-selective electrode in a flow-through manifold. The solid-contact sodium sensors had excellent stability in cleaned urine and an acceptable bias compared to commercial clinical analyzers.
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Details
- Title
- Measurement of sodium ion concentration in undiluted urine with cation-selective polymeric membrane electrodes after the removal of interfering compounds
- Creators
- Feyisayo Phillips - University of MemphisKim Kaczor - University of MemphisNeel Gandhi - University of MemphisBradford D. Pendley - University of MemphisRobert K. Danish - University of Tennessee Health Science CenterMichael R. Neuman - Michigan Technological UniversityBlanka Tóth - Budapest University of Technology and EconomicsViola Horváth - Budapest University of Technology and EconomicsErnö Lindner - University of Memphis
- Publication Details
- Talanta (Oxford), v 74(2), 255
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000251629800013
- Scopus ID
- 2-s2.0-36048966618
- Other Identifier
- 991021448168304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Analytical